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PMID: 20212493 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review Validation Study

Gene--environment-wide association studies: emerging approaches.

Nature reviews. Genetics ·Vol. 11 ·No. 4 ·2010-04-00 ·Pages 259-72

Thomas D

Abstract

Despite the yield of recent genome-wide association (GWA) studies, the identified variants explain only a small proportion of the heritability of most complex diseases. This unexplained heritability could be partly due to gene--environment (G×E) interactions or more complex pathways involving multiple genes and exposures. This Review provides a tutorial on the available epidemiological designs and statistical analysis approaches for studying specific G×E interactions and choosing the most appropriate methods. I discuss the approaches that are being developed for studying entire pathways and available techniques for mining interactions in GWA data. I also explore methods for marrying hypothesis-driven pathway-based approaches with 'agnostic' GWA studies.

MeSH Terms
Data Mining Environment Epigenesis, Genetic Genetic Predisposition to Disease Genome-Wide Association Study/methods,statistics & numerical data,trends Humans Models, Genetic Risk Factors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Thomas Duncan
Medicine, University of Southern California, 1540 Alcazar Street, CHP‑220, Los Angeles, California 90089‑9011, USA. dthomas@usc.edu
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2764
Email
dthomas@usc.edu
Published
2010-04-00
Pages
259-72
Language
English
Region
England
NLM ID
100962779
PMCID
PMC2891422
Subset
IM
Grants
NIEHS NIH HHS · U01 ES015090-01 · United States
NIEHS NIH HHS · P30 ES007048 · United States
NIEHS NIH HHS · U01 ES015090 · United States
NIEHS NIH HHS · P30 ES007048-029004 · United States
NIEHS NIH HHS · 5P30 ES007043 · United States
NIEHS NIH HHS · 1R01 ES016813 · United States
NIEHS NIH HHS · R01 ES019876 · United States
NIEHS NIH HHS · U01 ES015090-03 · United States
NIEHS NIH HHS · 1U01 ES15090 · United States
Corrections
CommentIn
PMID: 22094952
External Links
PubMed source DOI: 10.1038/nrg2764 PMC Full Text View journal details
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