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PMID: 20187240 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The role of parkin in familial and sporadic Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society ·Vol. 25 Suppl 1 ·2010-00-00 ·Pages S32-9

Dawson TM, Dawson VL

Abstract

Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD.

MeSH Terms
Animals Humans Mitochondria/metabolism Mutation/genetics Parkinson Disease/classification,genetics,metabolism,pathology Ubiquitin-Protein Ligases/genetics,metabolism
Chemicals
Ubiquitin-Protein Ligases parkin protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dawson Ted M
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. tdawson@jhmi.edu
Dawson Valina L
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Article Info
Journal
Movement disorders : official journal of the Movement Disorder Society
Abbr.
Mov Disord
ISSN
1531-8257
DOI
10.1002/mds.22798
Email
tdawson@jhmi.edu
Published
2010-00-00
Pages
S32-9
Language
English
Region
United States
NLM ID
8610688
PMCID
PMC4115293
Subset
IM
Grants
NINDS NIH HHS · P50 NS038377 · United States
NINDS NIH HHS · P50 NS38377 · United States
External Links
PubMed source DOI: 10.1002/mds.22798 PMC Full Text View journal details
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