Myc-modulated miR-9 makes more metastases.

Nature cell biology ·Vol. 12 ·No. 3 ·2010-03-00 ·Pages 209-11

Khew-Goodall Y, Goodall GJ

Abstract

The microRNA miR-9 is induced by Myc in breast cancer cells where it targets the major epithelial adherens junction protein, E-cadherin. This primes the cancer cells for epithelial-mesenchymal transition (EMT) and also stimulates angiogenesis in tumours.

MeSH Terms

Animals Antigens, CD Breast Neoplasms/metabolism,pathology Cadherins/genetics,metabolism Cell Proliferation Cell Transdifferentiation/genetics Down-Regulation/genetics Female Gene Expression Regulation, Neoplastic/physiology Humans Mice MicroRNAs/antagonists & inhibitors,physiology Models, Biological N-Myc Proto-Oncogene Protein Neoplasm Invasiveness/genetics,pathology Neoplasm Metastasis/genetics,pathology Neoplasms/metabolism,pathology Neovascularization, Pathologic/metabolism,pathology Neuroblastoma/metabolism Nuclear Proteins/genetics,metabolism Oncogene Proteins/genetics,metabolism Proto-Oncogene Proteins c-myc/genetics,metabolism Signal Transduction/physiology Transplantation, Heterologous/pathology Vascular Endothelial Growth Factor A/blood,genetics Vimentin/metabolism beta Catenin/genetics,metabolism

Chemicals

Antigens, CD CDH1 protein, human CTNNB1 protein, human Cadherins MIRN92 microRNA, human MYCN protein, human MicroRNAs N-Myc Proto-Oncogene Protein Nuclear Proteins Oncogene Proteins Proto-Oncogene Proteins c-myc VEGFA protein, human Vascular Endothelial Growth Factor A Vimentin beta Catenin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Khew-Goodall Yeesim

Centre for Cancer Biology, SA Pathology, Adelaide, Australia.

Goodall Gregory J

References (13)

13 references, click to expand

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Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1476-4679

DOI

10.1038/ncb0310-209

Published

2010-03-00

Epub

2010-00-21

Pages

209-11

Language

English

Region

England

NLM ID

100890575

Subset

Corrections

CommentOn

PMID: 20173740

External Links

PubMed source DOI: 10.1038/ncb0310-209 View journal details

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