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PMID: 2014973 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of a methicillin-resistant strain of Staphylococcus caprae from a human clinical specimen.

Antimicrobial agents and chemotherapy ·Vol. 35 ·No. 1 ·1991-01-00 ·Pages 174-6

Kanda K, Suzuki E, Hiramatsu K, Oguri T, Miura H, Ezaki T, Yokota T

Abstract

The analysis of gel banding patterns of penicillin-binding proteins was used to identify two clinical isolates of a coagulase-negative Staphylococcus species as Staphylococcus caprae, a species originally isolated from goat's milk. One of the isolates was further shown to carry mecA, the structural gene for methicillin resistance.

Related Genes

mecA

MeSH Terms

Animals Anti-Bacterial Agents/pharmacology Bacterial Proteins Carrier Proteins/metabolism Coagulase/metabolism DNA Probes Hexosyltransferases Humans Lactams Methicillin Resistance/genetics Microbial Sensitivity Tests Muramoylpentapeptide Carboxypeptidase/metabolism Penicillin-Binding Proteins Peptidyl Transferases Staphylococcus/enzymology,genetics

Chemicals

Anti-Bacterial Agents Bacterial Proteins Carrier Proteins Coagulase DNA Probes Lactams Penicillin-Binding Proteins Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Kanda K

Department of Microbiology, Faculty of Medicine, Juntendo University, Tokyo, Japan.

Suzuki E

Hiramatsu K

Oguri T

Miura H

Ezaki T

Yokota T

References (10)

10 references, click to expand

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Different staphylococcal species contain various numbers of penicillin-binding proteins ranging from four (Staphylococcus aureus) to only one (Staphylococcus hyicus).
J Bacteriol. 1985 Aug;163(2):796-8 PMID: 4019416
Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 1986 Dec;30(6):917-22 PMID: 3468883
Coagulase-negative staphylococci resistant to beta-lactam antibiotics in vivo produce penicillin-binding protein 2a.
Antimicrob Agents Chemother. 1987 Dec;31(12):1919-24 PMID: 3439802
Role of penicillinase plasmids in the stability of the mecA gene in methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 1990 Apr;34(4):600-4 PMID: 2344167
Cloning and expression of methicillin resistance from Staphylococcus epidermidis in Staphylococcus carnosus.
Antimicrob Agents Chemother. 1988 Oct;32(10):1494-9 PMID: 2903715
Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein.
J Bacteriol. 1989 May;171(5):2882-5 PMID: 2708325
Identification of coagulase-negative staphylococci by electrophoretic profile of total proteins and analysis of penicillin-binding proteins.
J Clin Microbiol. 1990 Mar;28(3):443-6 PMID: 2324271
Homology of mecA gene in methicillin-resistant Staphylococcus haemolyticus and Staphylococcus simulans to that of Staphylococcus aureus.
Antimicrob Agents Chemother. 1990 Jan;34(1):170-2 PMID: 1691614
Molecular epidemiology of multiresistant Staphylococcus epidermidis.
J Antimicrob Chemother. 1988 Apr;21 Suppl C:133-8 PMID: 3384767

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.35.1.174

Published

1991-01-00

Pages

174-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC244961

Subset

External Links

PubMed source DOI: 10.1128/AAC.35.1.174 PMC Full Text View journal details

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Identification of a methicillin-resistant strain of Staphylococcus caprae from a human clinical specimen.

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