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PMID: 20066120 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Adhesive and signaling functions of cadherins and catenins in vertebrate development.

Cold Spring Harbor perspectives in biology ·Vol. 1 ·No. 5 ·2009-11-00 ·Pages a002949

Stepniak E, Radice GL, Vasioukhin V

Abstract

Properly regulated intercellular adhesion is critical for normal development of all metazoan organisms. Adherens junctions play an especially prominent role in development because they link the adhesive function of cadherin-catenin protein complexes to the dynamic forces of the actin cytoskeleton, which helps to orchestrate a spatially confined and very dynamic assembly of intercellular connections. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are linked to several major developmental signaling pathways crucial for normal morphogenesis. In this article we will highlight the key genetic studies that uncovered the role of cadherin-catenin proteins in vertebrate development and discuss the potential role of these proteins as molecular biosensors of external cellular microenvironment that may spatially confine signaling molecules and polarity cues to orchestrate cellular behavior throughout the complex process of normal morphogenesis.

MeSH Terms
Actins/chemistry Adherens Junctions/metabolism Animals Brain/metabolism Cadherins/metabolism Catenins/metabolism Cell Adhesion Cell Proliferation Central Nervous System/metabolism Developmental Biology/methods Gene Expression Regulation Models, Biological Neural Crest/metabolism Signal Transduction
Chemicals
Actins Cadherins Catenins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stepniak Ewa
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Radice Glenn L
Vasioukhin Valeri
References (149)
149 references, click to expand
  1. Embryonic heart and skin defects in mice lacking plakoglobin.
    Dev Biol. 1996 Dec 15;180(2):780-5 PMID: 8954745
  2. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.
    Cell. 2006 Jun 2;125(5):957-69 PMID: 16751104
  3. Role of vascular endothelial-cadherin in vascular morphogenesis.
    Development. 1999 May;126(10):2093-102 PMID: 10207135
  4. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak.
    Development. 1993 Jul;118(3):829-44 PMID: 7521282
  5. Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac.
    J Cell Biol. 2004 Apr;165(1):87-98 PMID: 15067024
  6. Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.
    Nat Cell Biol. 2004 Dec;6(12):1212-20 PMID: 15543138
  7. Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.
    Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15399-404 PMID: 18809907
  8. Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation.
    Cancer Res. 2006 Dec 15;66(24):11967-74 PMID: 17178895
  9. beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis.
    J Biol Chem. 2003 Oct 10;278(41):40231-8 PMID: 12885771
  10. Directed actin polymerization is the driving force for epithelial cell-cell adhesion.
    Cell. 2000 Jan 21;100(2):209-19 PMID: 10660044
  11. Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.
    Genes Dev. 2003 Aug 15;17(16):1963-8 PMID: 12923052
  12. Wnt/beta-catenin signaling in development and disease.
    Cell. 2006 Nov 3;127(3):469-80 PMID: 17081971
  13. Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
    Genes Dev. 2004 Sep 15;18(18):2225-30 PMID: 15371335
  14. Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription.
    Nat Cell Biol. 2007 Aug;9(8):883-92 PMID: 17618275
  15. Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.
    Curr Biol. 2005 Sep 20;15(18):1677-83 PMID: 16169491
  16. Molecular bases of cell-cell junctions stability and dynamics.
    Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a002998 PMID: 20066121
  17. Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse.
    J Cell Biol. 2004 Aug 2;166(3):359-67 PMID: 15289495
  18. p120-catenin: Past and present.
    Biochim Biophys Acta. 2007 Jan;1773(1):2-7 PMID: 17175391
  19. Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer.
    Semin Cell Dev Biol. 2004 Dec;15(6):657-63 PMID: 15561585
  20. A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.
    Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):855-9 PMID: 7846066
  21. Differential adhesion leads to segregation and exclusion of N-cadherin-deficient cells in chimeric embryos.
    Dev Biol. 2001 Jun 1;234(1):72-9 PMID: 11356020
  22. Cadherin-11 in synovial lining formation and pathology in arthritis.
    Science. 2007 Feb 16;315(5814):1006-10 PMID: 17255475
  23. alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.
    Science. 2006 Mar 17;311(5767):1609-12 PMID: 16543460
  24. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.
    Cell. 1991 May 31;65(5):849-57 PMID: 1904011
  25. N-cadherin is required for neural crest remodeling of the cardiac outflow tract.
    Dev Biol. 2006 Nov 15;299(2):517-28 PMID: 17014840
  26. E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner.
    J Cell Biol. 2001 May 28;153(5):1049-60 PMID: 11381089
  27. Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling.
    PLoS One. 2008 Jan 30;3(1):e1516 PMID: 18231602
  28. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.
    J Cell Biol. 2006 Aug 14;174(4):593-604 PMID: 16893970
  29. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
    Nature. 2008 Apr 3;452(7187):650-3 PMID: 18385740
  30. Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.
    Development. 1999 Jan;126(2):371-81 PMID: 9847250
  31. Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.
    EMBO J. 2007 Mar 7;26(5):1456-66 PMID: 17318191
  32. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin.
    Cell. 2001 Feb 23;104(4):605-17 PMID: 11239416
  33. E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.
    EMBO J. 2005 Mar 23;24(6):1146-56 PMID: 15775979
  34. Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination.
    Development. 2007 Feb;134(3):491-501 PMID: 17185320
  35. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways.
    Cancer Res. 2008 May 15;68(10):3645-54 PMID: 18483246
  36. An alpha-E-catenin gene trap mutation defines its function in preimplantation development.
    Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):901-6 PMID: 9023354
  37. TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis.
    Genes Dev. 2007 Jul 15;21(14):1817-31 PMID: 17639085
  38. Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin.
    Development. 2001 Feb;128(4):459-69 PMID: 11171330
  39. New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.
    Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15405-10 PMID: 18809908
  40. Trabecular myocytes of the embryonic heart require N-cadherin for migratory unit identity.
    Dev Biol. 1998 Jan 1;193(1):1-9 PMID: 9466883
  41. Adhesive subdivisions intrinsic to the epithelial somites.
    Dev Biol. 1999 Nov 15;215(2):182-9 PMID: 10545229
  42. Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation.
    J Biol Chem. 2005 Jun 3;280(22):21129-36 PMID: 15778498
  43. alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.
    J Cell Sci. 2001 Sep;114(Pt 17):3177-88 PMID: 11590244
  44. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver.
    Proc Natl Acad Sci U S A. 2006 May 30;103(22):8419-24 PMID: 16714383
  45. p120-catenin mediates inflammatory responses in the skin.
    Cell. 2006 Feb 10;124(3):631-44 PMID: 16469707
  46. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon.
    Dev Biol. 2005 Mar 1;279(1):155-68 PMID: 15708565
  47. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.
    Genes Dev. 2008 Sep 1;22(17):2308-41 PMID: 18765787
  48. Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.
    Dev Cell. 2002 Aug;3(2):171-81 PMID: 12194849
  49. The cerebellar deficient folia (cdf) gene acts intrinsically in Purkinje cell migrations.
    Genesis. 2002 Jan;32(1):32-41 PMID: 11835672
  50. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.
    Dev Cell. 2006 Jan;10(1):21-31 PMID: 16399075
  51. Expression and cell membrane localization of catenins during mouse preimplantation development.
    Dev Dyn. 1996 Aug;206(4):391-402 PMID: 8853988
  52. E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
    Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8263-7 PMID: 8058792
  53. The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.
    Mol Cell Biol. 2002 Jul;22(13):4760-70 PMID: 12052883
  54. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.
    Cell. 1990 Sep 21;62(6):1073-85 PMID: 2205396
  55. Canonical WNT/beta-catenin signaling is required for ureteric branching.
    Dev Biol. 2008 May 1;317(1):83-94 PMID: 18358465
  56. Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.
    Cell. 2002 Nov 27;111(5):673-85 PMID: 12464179
  57. Misexpression of the catenin p120(ctn)1A perturbs Xenopus gastrulation but does not elicit Wnt-directed axis specification.
    Dev Biol. 1999 Mar 15;207(2):350-63 PMID: 10068468
  58. Targeted disruption of cadherin-11 leads to a reduction in bone density in calvaria and long bone metaphyses.
    J Bone Miner Res. 2001 Jul;16(7):1265-71 PMID: 11450702
  59. Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
    Cell. 2005 Mar 25;120(6):857-71 PMID: 15797385
  60. E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles.
    EMBO J. 2003 Nov 3;22(21):5723-33 PMID: 14592971
  61. Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.
    J Cell Biol. 1996 Oct;135(1):215-25 PMID: 8858175
  62. p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins.
    Neuron. 2006 Jul 6;51(1):43-56 PMID: 16815331
  63. Alpha N-catenin deficiency causes defects in axon migration and nuclear organization in restricted regions of the mouse brain.
    Dev Dyn. 2006 Sep;235(9):2559-66 PMID: 16691566
  64. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin.
    Cell. 1998 Nov 25;95(5):605-14 PMID: 9845363
  65. Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
    Cell. 1992 Jul 24;70(2):293-301 PMID: 1638632
  66. Cadherin-catenin proteins in vertebrate development.
    Curr Opin Cell Biol. 2006 Oct;18(5):499-506 PMID: 16859905
  67. Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.
    J Clin Invest. 2007 Jul;117(7):1794-804 PMID: 17607356
  68. Molecular evolution of the cadherin superfamily.
    Int J Biochem Cell Biol. 2009 Feb;41(2):349-69 PMID: 18848899
  69. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148.
    J Cell Biol. 2003 May 26;161(4):793-804 PMID: 12771128
  70. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor.
    Cancer Cell. 2002 Oct;2(4):301-14 PMID: 12398894
  71. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis.
    Dev Cell. 2005 May;8(5):739-50 PMID: 15866164
  72. Role of beta-catenin in the developing cortical and hippocampal neuroepithelium.
    Neuroscience. 2003;122(1):129-43 PMID: 14596855
  73. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture.
    Circulation. 2006 Sep 5;114(10):1046-55 PMID: 16923756
  74. SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling.
    Cancer Res. 2006 Feb 15;66(4):2279-86 PMID: 16489032
  75. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
    Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10894-9 PMID: 17576928
  76. Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses.
    Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):552-7 PMID: 14704278
  77. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation.
    J Biol Chem. 2000 Dec 29;275(52):41227-33 PMID: 10969083
  78. E-cadherin is a survival factor for the lactating mouse mammary gland.
    Mech Dev. 2002 Jul;115(1-2):53-62 PMID: 12049767
  79. Signaling from adherens-type junctions.
    Eur J Cell Biol. 2005 Mar;84(2-3):235-44 PMID: 15819404
  80. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
    Cell. 2001 May 18;105(4):533-45 PMID: 11371349
  81. Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.
    Proc Natl Acad Sci U S A. 2007 May 29;104(22):9313-8 PMID: 17519333
  82. Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses.
    Mol Cell Neurosci. 2000 Jun;15(6):534-46 PMID: 10860580
  83. Assembly of the cadherin-catenin complex in vitro with recombinant proteins.
    J Cell Sci. 1994 Dec;107 ( Pt 12):3655-63 PMID: 7706414
  84. Wnt signaling from development to disease: insights from model systems.
    Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a002881 PMID: 20066091
  85. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
    Nat Cell Biol. 2008 Aug;10(8):923-34 PMID: 18604199
  86. Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling.
    Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a002915 PMID: 20182623
  87. Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons.
    Dev Biol. 2000 Jul 1;223(1):38-53 PMID: 10864459
  88. Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
    Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18531-6 PMID: 18000065
  89. FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
    Leukemia. 2007 Dec;21(12):2476-84 PMID: 17851558
  90. E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions.
    Mol Biol Cell. 2007 Jun;18(6):2013-25 PMID: 17392517
  91. Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm.
    Development. 2006 Apr;133(7):1299-309 PMID: 16510506
  92. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.
    Cell. 2005 Dec 2;123(5):903-15 PMID: 16325583
  93. Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development.
    Dev Dyn. 2005 Jun;233(2):528-39 PMID: 15844200
  94. Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm.
    Development. 2007 Jan;134(1):31-41 PMID: 17138661
  95. Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion.
    Exp Cell Res. 1996 Jul 10;226(1):214-22 PMID: 8660958
  96. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
    Dev Cell. 2001 Jul;1(1):37-49 PMID: 11703922
  97. Precocious mammary gland development in P-cadherin-deficient mice.
    J Cell Biol. 1997 Nov 17;139(4):1025-32 PMID: 9362520
  98. Tight junctions/adherens junctions: basic structure and function.
    J Invest Dermatol. 2007 Nov;127(11):2525-32 PMID: 17934504
  99. Requirement for beta-catenin in anterior-posterior axis formation in mice.
    J Cell Biol. 2000 Feb 7;148(3):567-78 PMID: 10662781
  100. Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin.
    Dev Biol. 1997 May 15;185(2):261-71 PMID: 9187087
  101. Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.
    Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2322-7 PMID: 16452166
  102. EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.
    J Cell Biol. 2008 Sep 22;182(6):1217-30 PMID: 18794329
  103. Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice.
    Genomics. 2001 Jun 1;74(2):228-33 PMID: 11386759
  104. PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression.
    Development. 2008 Nov;135(21):3521-30 PMID: 18832396
  105. Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation.
    Nat Genet. 2002 Jul;31(3):279-84 PMID: 12089526
  106. p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
    Mol Cell Biol. 2003 Apr;23(7):2287-97 PMID: 12640114
  107. Multiple roles of mesenchymal beta-catenin during murine limb patterning.
    Development. 2006 Apr;133(7):1219-29 PMID: 16495310
  108. Maternal beta-catenin and E-cadherin in mouse development.
    Development. 2004 Sep;131(18):4435-45 PMID: 15306566
  109. VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
    EMBO J. 2008 Apr 9;27(7):993-1004 PMID: 18337748
  110. Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
    Genes Dev. 2003 Feb 1;17(3):394-409 PMID: 12569130
  111. Canonical Wnt signaling functions in second heart field to promote right ventricular growth.
    Proc Natl Acad Sci U S A. 2007 May 29;104(22):9319-24 PMID: 17519332
  112. N-cadherin mediates cortical organization in the mouse brain.
    Dev Biol. 2007 Apr 1;304(1):22-33 PMID: 17222817
  113. Phospho-regulation of Beta-catenin adhesion and signaling functions.
    Physiology (Bethesda). 2007 Oct;22:303-9 PMID: 17928543
  114. Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables.
    Nat Cell Biol. 2004 Jan;6(1):21-30 PMID: 14647292
  115. Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein (alpha-catenin).
    Genomics. 1993 Jan;15(1):13-20 PMID: 8432524
  116. An FGF-WNT gene regulatory network controls lung mesenchyme development.
    Dev Biol. 2008 Jul 15;319(2):426-36 PMID: 18533146
  117. Antagonism of cell adhesion by an alpha-catenin mutant, and of the Wnt-signaling pathway by alpha-catenin in Xenopus embryos.
    J Cell Biol. 1997 Nov 17;139(4):1033-46 PMID: 9362521
  118. N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis.
    J Cell Biol. 2005 Apr 11;169(1):29-34 PMID: 15809310
  119. EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
    Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9 PMID: 18093941
  120. Deconstructing the cadherin-catenin-actin complex.
    Cell. 2005 Dec 2;123(5):889-901 PMID: 16325582
  121. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss.
    Nat Genet. 2003 Sep;35(1):21-3 PMID: 12910270
  122. Lack of beta-catenin affects mouse development at gastrulation.
    Development. 1995 Nov;121(11):3529-37 PMID: 8582267
  123. E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases.
    EMBO J. 2004 Apr 21;23(8):1739-48 PMID: 15057284
  124. Developmental defects in mouse embryos lacking N-cadherin.
    Dev Biol. 1997 Jan 1;181(1):64-78 PMID: 9015265
  125. beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.
    Dev Biol. 2003 Jun 15;258(2):406-18 PMID: 12798297
  126. Neural crest emigration from the neural tube depends on regulated cadherin expression.
    Development. 1998 Aug;125(15):2963-71 PMID: 9655818
  127. parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube.
    Development. 2002 Jul;129(14):3281-94 PMID: 12091300
  128. Epicardium-derived progenitor cells require beta-catenin for coronary artery formation.
    Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18109-14 PMID: 17989236
  129. Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin.
    Mech Dev. 2004 Jan;121(1):91-9 PMID: 14706703
  130. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
    Biochim Biophys Acta. 2008 Mar;1778(3):660-9 PMID: 17854762
  131. Planar cell polarity: keeping hairs straight is not so simple.
    Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a003376 PMID: 20182624
  132. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
    Cell. 1999 Jul 23;98(2):147-57 PMID: 10428027
  133. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.
    Development. 2001 Apr;128(8):1253-64 PMID: 11262227
  134. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.
    Curr Opin Genet Dev. 2006 Feb;16(1):51-9 PMID: 16377174
  135. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
    Dev Cell. 2005 May;8(5):727-38 PMID: 15866163
  136. The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility.
    J Cell Biol. 2003 Sep 15;162(6):1111-22 PMID: 12975353
  137. Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation.
    J Neurosci. 2007 Mar 28;27(13):3466-76 PMID: 17392463
  138. Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages.
    Eur J Immunol. 2005 Mar;35(3):957-63 PMID: 15688343
  139. Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin.
    J Cell Biol. 1998 Jun 15;141(6):1433-48 PMID: 9628899
  140. Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state.
    Dev Biol. 2008 Feb 1;314(1):112-26 PMID: 18177851
  141. Genetic dissection of cadherin function during nephrogenesis.
    Mol Cell Biol. 2002 Mar;22(5):1474-87 PMID: 11839813
  142. Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.
    Development. 2007 Jul;134(13):2533-9 PMID: 17537789
  143. p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus.
    J Cell Sci. 2004 Aug 15;117(Pt 18):4325-39 PMID: 15292404
  144. alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain.
    J Cell Sci. 2008 May 1;121(Pt 9):1357-62 PMID: 18397997
  145. Lineage-specific requirements of beta-catenin in neural crest development.
    J Cell Biol. 2002 Dec 9;159(5):867-80 PMID: 12473692
  146. A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.
    Nat Cell Biol. 2008 Feb;10(2):186-93 PMID: 18157121
  147. Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia.
    Development. 2006 Dec;133(24):4839-47 PMID: 17108003
  148. Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.
    Development. 2008 Jan;135(1):85-94 PMID: 18045842
  149. Adherens junction: molecular architecture and regulation.
    Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a002899 PMID: 20457565
Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a002949
Published
2009-11-00
Pages
a002949
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC2773643
Subset
IM
Grants
NCI NIH HHS · R01 CA098161 · United States
NHLBI NIH HHS · R01 HL081569 · United States
NHLBI NIH HHS · HL081569 · United States
NCI NIH HHS · CA098161 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a002949 PMC Full Text View journal details
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