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PMID: 20059952 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Dual modes of cdc42 recycling fine-tune polarized morphogenesis.

Developmental cell ·Vol. 17 ·No. 6 ·2009-12-00 ·Pages 823-35

Slaughter BD, Das A, Schwartz JW, Rubinstein B, Li R

Abstract

In budding yeast, the highly conserved small GTPase Cdc42 localizes to the cortex at a cell pole and orchestrates the trafficking and deposition of cell surface materials required for building a bud or mating projection (shmoo). Using a combination of quantitative imaging and mathematical modeling, we elucidate mechanisms of dynamic recycling of Cdc42 that balance diffusion. Rdi1, a guanine nucleotide dissociation inhibitor (GDI), mediates a fast recycling pathway, while actin patch-mediated endocytosis accounts for a slower one. These recycling mechanisms are restricted to the same region of the nascent bud, as both are coupled to the Cdc42 GTPase cycle. We find that a single dynamic parameter, the rate of internalization inside the window of polarized delivery, is tuned to give rise to distinct shapes of Cdc42 distributions that correlate with distinct morphogenetic fates, such as the formation of a round bud or a pointed shmoo.

MeSH Terms
Cell Polarity Guanine Nucleotide Dissociation Inhibitors/metabolism Morphogenesis Saccharomyces cerevisiae/cytology Saccharomyces cerevisiae Proteins/metabolism cdc42 GTP-Binding Protein, Saccharomyces cerevisiae/metabolism
Chemicals
Guanine Nucleotide Dissociation Inhibitors Rdi1 protein, S cerevisiae Saccharomyces cerevisiae Proteins cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Slaughter Brian D
Stowers Institute for Medical Research, 1000 East 50(th) Street, Kansas City, MO 64110, USA.
Das Arupratan
Schwartz Joel W
Rubinstein Boris
Li Rong
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Article Info
Journal
Developmental cell
Abbr.
Dev Cell
ISSN
1878-1551
Published
2009-12-00
Pages
823-35
Language
English
Region
United States
NLM ID
101120028
PMCID
PMC2805562
Subset
IM
Grants
NIGMS NIH HHS · R01 GM057063-10 · United States
NIGMS NIH HHS · F32 GM077923 · United States
NIGMS NIH HHS · R01 GM057063-02 · United States
NIGMS NIH HHS · R01 GM057063 · United States
NIGMS NIH HHS · F32 GM077923-01A1 · United States
NIGMS NIH HHS · GM057063 · United States
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