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PMID: 200524 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae.

Genetics ·Vol. 87 ·No. 2 ·1977-10-00 ·Pages 229-36

Prakash S, Prakash L

Abstract

Methyl methanesulfonate (MMS)-sensitive mutants of Saccharomyces cerevisiae belonging to four different complementation groups, when homozygous, increase the rate of spontaneous mitotic segregation to canavanine resistance from heterozygous sensitive (canr/+) diploids by 13-to 170-fold. The mms8-1 mutant is MMS and X-ray sensitive and increases the rate of spontaneous mitotic segregation 170-fold. The mms9-1 and mms13-1 mutants are sensitive to X rays and UV, respectively, in addition of MMS, and increase the rate of spontaneous mitotic segregation by 13-fold and 85-fold, respectively. The mutant mms21-1 is sensitive to MMS, X rays and UV and increases the rate of spontaneous mitotic segregation 23-fold.

MeSH Terms

Canavanine/pharmacology DNA Repair DNA, Single-Stranded Drug Resistance, Microbial/radiation effects Genetic Complementation Test Meiosis Mesylates/pharmacology Methyl Methanesulfonate/pharmacology Saccharomyces cerevisiae/drug effects,genetics,radiation effects Ultraviolet Rays X-Rays

Chemicals

DNA, Single-Stranded Mesylates Canavanine Methyl Methanesulfonate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Prakash S

Prakash L

References (11)

11 references, click to expand

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Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/87.2.229

Published

1977-10-00

Pages

229-36

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1213736

Subset

External Links

PubMed source DOI: 10.1093/genetics/87.2.229 PMC Full Text View journal details

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Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae.

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