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PMID: 20036613 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases.

Current opinion in microbiology ·Vol. 13 ·No. 1 ·2010-02-00 ·Pages 41-6

Hicks SW, Galán JE

Abstract

Ubiquitinylation of proteins is a critical mechanism in regulating numerous eukaryotic cellular processes including cell cycle progression, inflammatory response, and vesicular trafficking. Given the importance of ubiquitinylation, it is not surprising that several pathogenic bacteria have developed strategies to exploit various stages of the ubiquitin pathway for their own benefit. One such strategy is the delivery of bacterial 'effector' proteins into the host cell cytosol, which mimic the activities of components of the host ubiquitin pathway. Recent studies have highlighted a number of bacterial effectors that functionally mimic the activity of eukaryotic E3 ubiquitin ligases, including a novel structural class of bacterial E3 ligases that provides a striking example of convergent evolution.

MeSH Terms
Bacteria/pathogenicity Bacterial Proteins/chemistry,genetics,metabolism Eukaryotic Cells/microbiology Evolution, Molecular Gene Expression Regulation Protein Structure, Tertiary Protein Transport Ubiquitin/metabolism Ubiquitin-Protein Ligases/chemistry,genetics,metabolism Ubiquitination/physiology Virulence Factors/chemistry,genetics,metabolism
Chemicals
Bacterial Proteins Ubiquitin Virulence Factors Ubiquitin-Protein Ligases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hicks Stuart W
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Galán Jorge E
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Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1879-0364
DOI
10.1016/j.mib.2009.11.008
Published
2010-02-00
Epub
2009-00-28
Pages
41-6
Language
English
Region
England
NLM ID
9815056
PMCID
PMC2822022
Subset
IM
Grants
NIAID NIH HHS · AI055472 · United States
NIAID NIH HHS · R01 AI055472-15 · United States
NIAID NIH HHS · R01 AI055472-10 · United States
NIAID NIH HHS · R01 AI055472-14 · United States
NIAID NIH HHS · AI069704 · United States
NIAID NIH HHS · R01 AI055472 · United States
NIAID NIH HHS · R01 AI055472-12 · United States
NIAID NIH HHS · R01 AI055472-16 · United States
NIAID NIH HHS · R01 AI055472-13 · United States
NIAID NIH HHS · F32 AI069704 · United States
NIAID NIH HHS · R01 AI055472-11 · United States
External Links
PubMed source DOI: 10.1016/j.mib.2009.11.008 PMC Full Text View journal details
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