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PMID: 18516089 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series.

EMBO reports ·Vol. 9 ·No. 6 ·2008-06-00 ·Pages 536-42

Ikeda F, Dikic I

Abstract

Ubiquitin (Ub) is a small protein modifier that regulates many biological processes, including gene transcription, cell-cycle progression, DNA repair, apoptosis, virus budding and receptor endocytosis. Ub can be conjugated to target proteins either as a monomer or as Ub chains that vary in length and linkage type. The various types of Ub modification are linked to distinct physiological functions in cells. MonoUb, for example, regulates DNA repair and receptor endocytosis, whereas lysine 48-linked Ub chains label proteins for proteasomal degradation. More recently, the importance of chains conjugated through the other six lysines in Ub, known as atypical Ub chains, has been revealed. Atypical chains can be homotypic, sequentially using the same lysine residue in Ub for conjugation; mixed-linkage, utilizing several distinct lysines to connect consecutive Ub moieties; or heterologous, connecting Ub with other Ub-like modifiers. Here, we describe recent progress in the understanding of atypical Ub chain assembly and their recognition by Ub-binding domains, and we discuss further their functional roles in vivo.

MeSH Terms
Models, Molecular Polyubiquitin/chemistry,classification,metabolism Protein Binding Protein Processing, Post-Translational Protein Structure, Tertiary Signal Transduction/physiology
Chemicals
Polyubiquitin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ikeda Fumiyo
Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt (Main), Germany. ikeda@medils.hr
Dikic Ivan
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-3178
DOI
10.1038/embor.2008.93
Email
ikeda@medils.hr
Published
2008-06-00
Pages
536-42
Language
English
Region
England
NLM ID
100963049
PMCID
PMC2427391
Subset
IM
Corrections
CommentIn
PMID: 18516080
External Links
PubMed source DOI: 10.1038/embor.2008.93 PMC Full Text View journal details
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