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PMID: 200144 Published · ppublish English Journal Article

Considerations on the preneoplastic lesions of the mammary gland.

The American journal of pathology ·Vol. 89 ·No. 2 ·1977-11-00 ·Pages 413-30

Gullino PM

Abstract

The general characteristics of the preneoplastic lesions of the human mammary gland, as they are known through histologic description, are outlined, and data obtained from the experimental analysis of mammary gland preneoplasia in five areas of endeavor are discussed. Results obtained with transplantation procedures and aimed at defining the growth potential of hyperplastic outgrowths are reported. Information derived from the study of events able to induce benign hyperplastic outgrowths or their malignant transformation in the murine mammary gland is summarized. Attempts to predict neoplastic transformation in morphologically hyperplastic epithelium of human and rodent glands are discussed. The present status of efforts toward the prophylaxis of preneoplastic lesions of the mammary gland is described. Considerations of the relationship between preneoplasia and tumor dormancy conclude the presentation.

MeSH Terms
9,10-Dimethyl-1,2-benzanthracene Animals Breast/pathology Breast Neoplasms/pathology Bromocriptine/therapeutic use Cell Transformation, Neoplastic/pathology Cells, Cultured Ergolines/therapeutic use Female Humans Hyperplasia Mammary Neoplasms, Experimental/chemically induced,drug therapy,pathology Mammary Tumor Virus, Mouse Mice Neoplasm Transplantation Precancerous Conditions/pathology Transplantation, Heterologous Urethane
Chemicals
Ergolines Bromocriptine Urethane 9,10-Dimethyl-1,2-benzanthracene
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gullino P M
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1977-11-00
Pages
413-30
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032232
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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