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PMID: 1190292 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The resistance of certain tissues to invasion. III. Cartilage extracts inhibit the growth of fibroblasts and endothelial cells in culture.

The American journal of pathology ·Vol. 81 ·No. 2 ·1975-11-00 ·Pages 337-48

Eisenstein R, Kuettner KE, Neapolitan C, Soble LW, Sorgente N

Abstract

Extracts of bovine dermis and cartilage inhibit the growth of bovine endothelial cells more than that of most of the fibroblast types tested. Extracts of cartilage, a tissue rather resistant to invasion, inhibit the growth of endothelial cells more than extracts of dermis do. Since such extracts contain antiproteolytic activity, it is suggested that the inhibition of cell growth they induce is effected by protease inhibitors native to connective tissues.

MeSH Terms

Animals Aorta/drug effects Cartilage Cattle Cell Division/drug effects Cells, Cultured Dose-Response Relationship, Drug Endothelium/cytology,drug effects Fibroblasts/drug effects Guanidines/pharmacology Humans In Vitro Techniques Skin Tissue Extracts/pharmacology Trypsin Inhibitor, Bowman-Birk Soybean/pharmacology

Chemicals

Guanidines Tissue Extracts Trypsin Inhibitor, Bowman-Birk Soybean

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Eisenstein R

Kuettner K E

Neapolitan C

Soble L W

Sorgente N

References (12)

12 references, click to expand

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Proteinase inhibitor activity in connective tissues.
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The resistance of certain tissues to invasion: penetrability of explanted tissues by vascularized mesenchyme.
Am J Pathol. 1973 Dec;73(3):765-74 PMID: 4129060
Human vascular endothelial cells in culture. Growth and DNA synthesis.
J Cell Biol. 1974 Mar;60(3):673-84 PMID: 4363161
Effect of inhibitors of proteolytic enzymes on the growth of normal and polyoma transformed BHK cells.
Biochem Biophys Res Commun. 1974 Sep 9;60(1):348-54 PMID: 4370770
Surface changes in transformed cells detected by lectins.
Fed Proc. 1973 Jan;32(1):91-101 PMID: 4346328
Fibrinolysis associated with oncogenic transformation. Requirement of plasminogen for correlated changes in cellular morphology, colony formation in agar, and cell migration.
J Exp Med. 1973 Nov 1;138(5):1056-64 PMID: 4355423
Replication of human endothelial cells in culture.
Science. 1973 Aug 3;181(4098):453-4 PMID: 4718112
Population dynamics of arterial smooth-muscle cells. II. In vivo inhibition of entry into mitosis of swine arterial smooth-muscle cells by aortic tissue extracts.
Arch Pathol. 1973 May;95(5):317-20 PMID: 4694073
The resistance of certain tissues to invasion. II. Evidence for extractable factors in cartilage which inhibit invasion by vascularized mesenchyme.
Lab Invest. 1975 Feb;32(2):217-22 PMID: 1113513
Inhibition of tumor angiogenesis mediated by cartilage.
J Exp Med. 1975 Feb 1;141(2):427-39 PMID: 1113064
Proteinpolysaccharide complex from bovine nasal cartilage. The function of glycoprotein in the formation of aggregates.
J Biol Chem. 1969 May 10;244(9):2384-96 PMID: 5783840

Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1975-11-00

Pages

337-48

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC2032220

Subset

External Links

PubMed source PMC Full Text View journal details

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The resistance of certain tissues to invasion. III. Cartilage extracts inhibit the growth of fibroblasts and endothelial cells in culture.

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