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PMID: 20010958 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Effects of AMP-activated protein kinase in cerebral ischemia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism ·Vol. 30 ·No. 3 ·2010-03-00 ·Pages 480-92

Li J, McCullough LD

Abstract

AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK is found in most mammalian tissues including the brain. As a key metabolic and stress sensor/effector, AMPK is activated under conditions of nutrient deprivation, vigorous exercise, or heat shock. However, it is becoming increasingly recognized that changes in AMPK activation not only signal unmet metabolic needs, but also are involved in sensing and responding to 'cell stress', including ischemia. The downstream effect of AMPK activation is dependent on many factors, including the severity of the stressor as well as the tissue examined. This review discusses recent in vitro and in vivo studies performed in the brain/neuronal cells and vasculature that have contributed to our understanding of AMPK in stroke. Recent data on the potential role of AMPK in angiogenesis and neurogenesis and the interaction of AMPK with 3-hydroxy-3-methy-glutaryl-CoA reductase inhibitors (statins) agents are highlighted. The interaction between AMPK and nitric oxide signaling is also discussed.

MeSH Terms
AMP-Activated Protein Kinases/physiology Animals Blood Vessels/enzymology,physiology Brain Chemistry Brain Ischemia/enzymology,physiopathology Cerebrovascular Circulation/physiology Gene Expression Regulation, Enzymologic Humans Isoenzymes/physiology Nitric Oxide/physiology Stroke/enzymology
Chemicals
Isoenzymes Nitric Oxide AMP-Activated Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Li Jun
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
McCullough Louise D
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Article Info
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Abbr.
J Cereb Blood Flow Metab
ISSN
1559-7016
DOI
10.1038/jcbfm.2009.255
Published
2010-03-00
Epub
2009-00-16
Pages
480-92
Language
English
Region
United States
NLM ID
8112566
PMCID
PMC2852687
Subset
IM
Grants
NINDS NIH HHS · R01 NS050505 · United States
NINDS NIH HHS · R01 NS050505-05 · United States
NINDS NIH HHS · R01 NS055215 · United States
NINDS NIH HHS · NS055215 · United States
External Links
PubMed source DOI: 10.1038/jcbfm.2009.255 PMC Full Text View journal details
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