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PMID: 1996358 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Resolution of the African hominoid trichotomy by use of a mitochondrial gene sequence.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 4 ·1991-02-15 ·Pages 1570-4

Ruvolo M, Disotell TR, Allard MW, Brown WM, Honeycutt RL

Abstract

Mitochondrial DNA sequences encoding the cytochrome oxidase subunit II gene have been determined for five primate species, siamang (Hylobates syndactylus), lowland gorilla (Gorilla gorilla), pygmy chimpanzee (Pan paniscus), crab-eating macaque (Macaca fascicularis), and green monkey (Cercopithecus aethiops), and compared with published sequences of other primate and nonprimate species. Comparisons of cytochrome oxidase subunit II gene sequences provide clear-cut evidence from the mitochondrial genome for the separation of the African ape trichotomy into two evolutionary lineages, one leading to gorillas and the other to humans and chimpanzees. Several different tree-building methods support this same phylogenetic tree topology. The comparisons also yield trees in which a substantial length separates the divergence point of gorillas from that of humans and chimpanzees, suggesting that the lineage most immediately ancestral to humans and chimpanzees may have been in existence for a relatively long time.

MeSH Terms
Animals Base Sequence Biological Evolution DNA, Mitochondrial/genetics Genes Genetic Variation Hominidae/genetics Humans Molecular Sequence Data Oligonucleotide Probes Phylogeny Primates/genetics Vertebrates/genetics
Chemicals
DNA, Mitochondrial Oligonucleotide Probes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ruvolo M
Department of Anthropology, Harvard University, Cambridge, MA 02138.
Disotell T R
Allard M W
Brown W M
Honeycutt R L
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.4.1570
Published
1991-02-15
Pages
1570-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51061
Subset
IM
Grants
NIGMS NIH HHS · GM30144 · United States
Databases
GENBANK
M58005, M58006, M58007, M58008, M58009, S74653, S74655, S74658, S74661, S74663
External Links
PubMed source DOI: 10.1073/pnas.88.4.1570 PMC Full Text View journal details
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