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PMID: 19960040 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Macrophage death and defective inflammation resolution in atherosclerosis.

Nature reviews. Immunology ·Vol. 10 ·No. 1 ·2010-01-00 ·Pages 36-46

Tabas I

Abstract

A key event in atherosclerosis is a maladaptive inflammatory response to subendothelial lipoproteins. A crucial aspect of this response is a failure to resolve inflammation, which normally involves the suppression of inflammatory cell influx, effective clearance of apoptotic cells and promotion of inflammatory cell egress. Defects in these processes promote the progression of atherosclerotic lesions into dangerous plaques, which can trigger atherothrombotic vascular disease, the leading cause of death in industrialized societies. In this Review I provide an overview of these concepts, with a focus on macrophage death and defective apoptotic cell clearance, and discuss new therapeutic strategies designed to boost inflammation resolution in atherosclerosis.

MeSH Terms
Animals Apoptosis/immunology Atherosclerosis/immunology,pathology,therapy Humans Inflammation/immunology,pathology,therapy Macrophage Activation/immunology Macrophages/immunology,pathology Phagocytosis/immunology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Tabas Ira
Department of Medicine, Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA. iat1@columbia.edu
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2675
Email
iat1@columbia.edu
Published
2010-01-00
Epub
2009-00-04
Pages
36-46
Language
English
Region
England
NLM ID
101124169
PMCID
PMC2854623
Subset
IM
Grants
NHLBI NIH HHS · HL75662 · United States
NHLBI NIH HHS · P01 HL054591 · United States
NHLBI NIH HHS · R01 HL075662 · United States
NHLBI NIH HHS · HL54591 · United States
NHLBI NIH HHS · P01 HL054591-140004 · United States
NHLBI NIH HHS · R01 HL075662-07 · United States
External Links
PubMed source DOI: 10.1038/nri2675 PMC Full Text View journal details
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