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PMID: 15280540 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 101 ·No. 32 ·2004-08-10 ·Pages 11779-84

Llodrá J, Angeli V, Liu J, Trogan E, Fisher EA, Randolph GJ

Abstract

Some monocytes normally take up residence in tissues as sessile macrophages, but others differentiate into migratory cells resembling dendritic cells that emigrate to lymph nodes. In an in vitro model of a vessel wall, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated in promoting atherosclerosis, blocked conversion of monocytes into migratory cells and favored their retention in the subendothelium. In vivo studies revealed trafficking of monocyte-derived cells from atherosclerotic plaques during lesion regression, but little emigration was detected from progressive plaques. Thus, progression of atherosclerotic plaques may result not only from robust monocyte recruitment into arterial walls but also from reduced emigration of these cells from lesions.

MeSH Terms
Animals Aorta, Thoracic/pathology,transplantation Apolipoproteins E/genetics Arteriosclerosis/etiology,pathology Cell Movement Disease Progression Endothelium, Vascular/pathology Female Kinetics Lipids/pharmacology Lysophospholipids/pharmacology Male Mice Mice, Knockout Monocytes/pathology,physiology Platelet Activating Factor/pharmacology Transplantation, Homologous
Chemicals
Apolipoproteins E Lipids Lysophospholipids Platelet Activating Factor lysophosphatidic acid
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Llodrá Jaime
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Angeli Véronique
Liu Jianhua
Trogan Eugene
Fisher Edward A
Randolph Gwendalyn J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0403259101
Published
2004-08-10
Epub
2004-00-27
Pages
11779-84
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC511052
Subset
IM
Grants
NIAID NIH HHS · R37 AI049653 · United States
NHLBI NIH HHS · R01 HL069446 · United States
NIAID NIH HHS · R01 AI049653 · United States
NIAID NIH HHS · AI49653 · United States
NHLBI NIH HHS · HL69446 · United States
NHLBI NIH HHS · HL61814 · United States
Corrections
CommentIn
PMID: 15292506
External Links
PubMed source DOI: 10.1073/pnas.0403259101 PMC Full Text View journal details
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