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PMID: 19957922 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity.

The Journal of organic chemistry ·Vol. 75 ·No. 1 ·2010-01-01 ·Pages 2-10

Singh AJ, Xu CX, Xu X, West LM, Wilmes A, Chan A, Hamel E, Miller JH, Northcote PT, Ghosh AK

Abstract

Peloruside B (2), a natural congener of peloruside A (1), was isolated in sub-milligram quantities from the New Zealand marine sponge Mycale hentscheli. Peloruside B promotes microtubule polymerization and arrests cells in the G(2)/M phase of mitosis similar to paclitaxel, and its bioactivity was comparable to that of peloruside A. NMR-directed isolation, structure elucidation, structure confirmation by total synthesis, and bioactivity of peloruside B are described in this article. The synthesis features Sharpless dihydroxylation, Brown's asymmetric allylboration reaction, reductive aldol coupling, Yamaguchi macrolactonization, and selective methylation.

MeSH Terms
Animals Antineoplastic Agents/chemical synthesis,isolation & purification,pharmacology Bridged Bicyclo Compounds, Heterocyclic/chemistry,pharmacology Cell Cycle/drug effects Lactones/chemical synthesis,chemistry,isolation & purification,pharmacology Macrolides/chemical synthesis,chemistry,isolation & purification,pharmacology Magnetic Resonance Spectroscopy Molecular Structure New Zealand Paclitaxel/chemistry,pharmacology Porifera/chemistry
Chemicals
Antineoplastic Agents Bridged Bicyclo Compounds, Heterocyclic Lactones Macrolides peloruside A peloruside B Paclitaxel
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Singh A Jonathan
Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.
Xu Chun-Xiao
Xu Xiaoming
West Lyndon M
Wilmes Anja
Chan Ariane
Hamel Ernest
Miller John H
Northcote Peter T
Ghosh Arun K
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Article Info
Journal
The Journal of organic chemistry
Abbr.
J Org Chem
ISSN
1520-6904
Published
2010-01-01
Pages
2-10
Language
English
Region
United States
NLM ID
2985193R
PMCID
PMC2812918
Subset
IM
Grants
NIGMS NIH HHS · R01 GM053386 · United States
NIGMS NIH HHS · R01 GM053386-15 · United States
NIGMS NIH HHS · R37 GM053386 · United States
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