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PMID: 18283613 Published · ppublish English Journal Article Review

Strategies for the synthesis of the novel antitumor agent peloruside A.

Current opinion in drug discovery & development ·Vol. 11 ·No. 2 ·2008-03-00 ·Pages 251-71

Williams DR, Nag PP, Zorn N

Abstract

The microtubule-stabilizing agent (+)-peloruside A has emerged as a potential therapeutic agent for the treatment of cancer. Two total syntheses have been published and these reports have stimulated additional studies to advance the methodology and strategies for accessing this molecular architecture. This review details the biological data, modeling and conformation analyses, and synthetic studies toward the synthesis of (+)-peloruside A, that were reported prior to December 2007.

MeSH Terms
Animals Antibiotics, Antineoplastic/chemical synthesis,chemistry,pharmacology Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis,chemistry,pharmacology Humans Indicators and Reagents Lactones/chemical synthesis,chemistry,pharmacology Models, Molecular Neoplasms/drug therapy,pathology Structure-Activity Relationship
Chemicals
Antibiotics, Antineoplastic Bridged Bicyclo Compounds, Heterocyclic Indicators and Reagents Lactones peloruside A
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Williams David R
Indiana University, Department of Chemistry, 800 East Kirkwood Avenue, Bloomington, IN 47450, USA. williamd@indiana.edu
Nag Partha P
Zorn Nicolas
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Article Info
Journal
Current opinion in drug discovery & development
Abbr.
Curr Opin Drug Discov Devel
ISSN
1367-6733
Email
williamd@indiana.edu
Published
2008-03-00
Pages
251-71
Language
English
Region
England
NLM ID
100887519
PMCID
PMC2693484
Subset
IM
Grants
NIGMS NIH HHS · R01 GM041560-23A2 · United States
NIGMS NIH HHS · R01 GM041560-24 · United States
External Links
PubMed source PMC Full Text View journal details
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