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PMID: 19912250 Published · ppublish English Journal Article Review

Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?

Clinical and experimental immunology ·Vol. 159 ·No. 2 ·2010-02-00 ·Pages 131-6

Koenders MI, van den Berg WB

Abstract

In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.

MeSH Terms
Animals Autoimmune Diseases/immunology,metabolism Autoimmunity/immunology Encephalomyelitis, Autoimmune, Experimental/genetics,immunology,metabolism Humans Interleukin-17/genetics,immunology,metabolism Mice Mice, Knockout T-Lymphocytes, Helper-Inducer/cytology,immunology,metabolism
Chemicals
Interleukin-17
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Koenders M I
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
van den Berg W B
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
1365-2249
DOI
10.1111/j.1365-2249.2009.04039.x
Published
2010-02-00
Epub
2009-00-11
Pages
131-6
Language
English
Region
England
NLM ID
0057202
PMCID
PMC2810381
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2249.2009.04039.x PMC Full Text View journal details
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