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PMID: 19912248 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells.

Clinical and experimental immunology ·Vol. 159 ·No. 2 ·2010-02-00 ·Pages 148-58

de Jong E, Suddason T, Lord GM

Abstract

There has been a considerable amount of interest in the immunological community about new phenotypic subsets of CD4(+) T cells, particularly cells that produce the cytokine interleukin (IL)-17 [named T helper type 17 (Th17) cells]. While the initial discovery of Th17 cells and the pathways that controlled their development was in the mouse, recent attention has shifted to the existence of these cells and the relevant upstream cytokine signals in humans. While it is clear that CD4(+) T cells producing IL-17 exist in vivo, their relevance to disease pathogenesis is only just being understood. In this paper, we review the data regarding the generation of human Th17 cells in vitro and the evidence that this effector population is important in human disease states.

MeSH Terms
Animals Cell Lineage Dendritic Cells/cytology,immunology,metabolism Humans Interleukin-17/immunology,metabolism Mice Models, Biological T-Lymphocytes, Helper-Inducer/cytology,immunology,metabolism Th1 Cells/cytology,immunology,metabolism Th2 Cells/cytology,immunology,metabolism
Chemicals
Interleukin-17
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
de Jong E
Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Meibergdreef, AZ Amsterdam, the Netherlands.
Suddason T
Lord G M
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
1365-2249
DOI
10.1111/j.1365-2249.2009.04041.x
Published
2010-02-00
Epub
2009-00-11
Pages
148-58
Language
English
Region
England
NLM ID
0057202
PMCID
PMC2810383
Subset
IM
Grants
Medical Research Council · G0802068 · United Kingdom
Biotechnology and Biological Sciences Research Council · United Kingdom
External Links
PubMed source DOI: 10.1111/j.1365-2249.2009.04041.x PMC Full Text View journal details
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