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PMID: 19884256 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The dosage compensation complex shapes the conformation of the X chromosome in Drosophila.

Genes & development ·Vol. 23 ·No. 21 ·2009-11-01 ·Pages 2490-5

Grimaud C, Becker PB

Abstract

The dosage compensation complex (DCC) in Drosophila globally increases transcription from the X chromosome in males to compensate for its monosomy. We discovered a male-specific conformation of the X chromosome that depends on the associations of high-affinity binding sites (HAS) of the DCC. The core DCC subunits MSL1-MSL2 are responsible for this male-specific organization. Contrary to emerging concepts, we found that neither DCC assembly nor the conformation of the male X chromosome are influenced by nuclear pore components. We propose that nuclear organization of HAS is central to the faithful distribution of the DCC along the X chromosome.

MeSH Terms
Animals Cell Nucleus/metabolism Dosage Compensation, Genetic Drosophila Proteins/metabolism Drosophila melanogaster/genetics Embryonic Development Interphase/genetics Male Protein Binding X Chromosome/chemistry,genetics
Chemicals
Drosophila Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Grimaud Charlotte
Adolf-Butenandt-Institute and Centre for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, 80336 Munich, Germany.
Becker Peter B
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
DOI
10.1101/gad.539509
Published
2009-11-01
Pages
2490-5
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC2779748
Subset
IM
External Links
PubMed source DOI: 10.1101/gad.539509 PMC Full Text View journal details
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