A TRANSPLANTABLE RABBIT CARCINOMA ORIGINATING IN A VIRUS-INDUCED PAPILLOMA AND CONTAINING THE VIRUS IN MASKED OR ALTERED FORM.
A squamous cell carcinoma derived from a virus-induced rabbit papilloma has been propagated in fourteen successive groups of animals. It grows rapidly now in most individuals to which it is transplanted, killing early and metastasizing frequently. The original cancer was the outcome of alterations in epidermal cells already rendered neoplastic by the virus, and the latter, or an agent nearly related to it, has persisted and increased in the malignant tissue, as a study of the blood of the first ten groups of cancerous animals has shown. An antibody capable of specifically neutralizing the virus in vitro appeared in the blood of every new host in which the tumor enlarged progressively, and reached a titer comparable with that obtaining in animals which had long carried large papillomas. The antibody was absent from normal rabbits and those in which the cancer failed to grow. The implications of these facts are considered.
19 references, click to expand
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SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS : II. TESTS OF THE BLOOD OF ANIMALS CARRYING VARIOUS EPITHELIAL TUMORS.J Exp Med. 1936 Jun 30;64(1):79-96 PMID: 19870525
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INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY.J Exp Med. 1933 Oct 31;58(5):607-24 PMID: 19870219
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SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS : I. TESTS OF THE BLOOD OF ANIMALS CARRYING THE PAPILLOMA.J Exp Med. 1936 Jun 30;64(1):63-77 PMID: 19870523
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THE CARCINOGENIC EFFECT OF A PAPILLOMA VIRUS ON THE TARRED SKIN OF RABBITS : II. MAJOR FACTORS DETERMINING THE PHENOMENON: THE MANIFOLD EFFECTS OF TARRING.J Exp Med. 1938 Sep 30;68(4):529-62 PMID: 19870803
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A Study of Inheritance in Mice with Reference to their Susceptibility to transplantable Tumors.J Med Res. 1909 Oct;21(3):519-73 PMID: 19971930
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THE PROGRESSION TO CARCINOMA OF VIRUS-INDUCED RABBIT PAPILLOMAS (SHOPE).J Exp Med. 1935 Sep 30;62(4):523-48 PMID: 19870432
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ON THE GREATER SUSCEPTIBILITY OF AN ALIEN VARIETY OF HOST TO AN AVIAN TUMOR.J Exp Med. 1914 Oct 1;20(4):413-8 PMID: 19867831
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UTERINE ADENOMATA IN THE RABBIT : I. CLINICAL HISTORY, PATHOLOGY AND PRELIMINARY TRANSPLANTATION EXPERIMENTS.J Exp Med. 1938 Apr 30;67(5):691-708 PMID: 19870749
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RESISTANCE TO A TUMOR-PRODUCING AGENT AS DISTINCT FROM RESISTANCE TO THE IMPLANTED TUMOR CELLS : OBSERVATIONS WITH A SARCOMA OF THE FOWL.J Exp Med. 1913 Oct 1;18(4):416-27 PMID: 19867717
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IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : I. DEMONSTRATION OF A COMPLEMENT FIXATION REACTION: RELATION OF VIRUS-NEUTRALIZING AND COMPLEMENT-BINDING ANTIBODIES.J Exp Med. 1938 Oct 31;68(5):703-24 PMID: 19870812
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THE FIXATION AND PROTECTION OF VIRUSES BY THE CELLS OF SUSCEPTIBLE ANIMALS.J Exp Med. 1935 Apr 30;61(5):657-88 PMID: 19870384
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A DISTINCTIVE SUBSTANCE ASSOCIATED WITH THE BROWN-PEARCE RABBIT CARCINOMA : I. PRESENCE AND SPECIFICITY OF THE SUBSTANCE AS DETERMINED BY SERUM REACTIONS.J Exp Med. 1940 Feb 29;71(3):335-50 PMID: 19870967
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A COMPARISON OF VIRUS-INDUCED RABBIT TUMORS WITH THE TUMORS OF UNKNOWN CAUSE ELICITED BY TARRING.J Exp Med. 1939 Feb 28;69(3):399-424 PMID: 19870854
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OBSERVATIONS ON THE RELATION OF THE VIRUS CAUSING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM : II. THE EVIDENCE PROVIDED BY THE TUMORS: GENERAL CONSIDERATIONS.J Exp Med. 1936 Aug 31;64(3):401-24 PMID: 19870544
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IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : III. ANTIGENICITY AND PATHOGENICITY OF EXTRACTS OF THE GROWTHS OF WILD AND DOMESTIC SPECIES: GENERAL DISCUSSION.J Exp Med. 1938 Oct 31;68(5):737-59 PMID: 19870814
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THE CARCINOGENIC EFFECT OF A VIRUS UPON TARRED SKIN.Science. 1936 May 15;83(2159):468-9 PMID: 17796848
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STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : I. THE SPONTANEOUS TUMOR AND ASSOCIATED ABNORMALITIES.J Exp Med. 1923 Apr 30;37(5):601-29 PMID: 19868747
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THE ACTIVATING, TRANSFORMING, AND CARCINOGENIC EFFECTS OF THE RABBIT PAPILLOMA VIRUS (SHOPE) UPON IMPLANTED TAR TUMORS.J Exp Med. 1940 May 31;71(6):787-812 PMID: 19870999
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CANCERS DERIVING FROM THE VIRUS PAPILLOMAS OF WILD RABBITS UNDER NATURAL CONDITIONS.J Exp Med. 1940 Mar 31;71(4):469-94 PMID: 19870976
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