RESISTANCE TO A TUMOR-PRODUCING AGENT AS DISTINCT FROM RESISTANCE TO THE IMPLANTED TUMOR CELLS : OBSERVATIONS WITH A SARCOMA OF THE FOWL.

Ultraviolet light rapidly kills the cells of a transplantable sarcoma of the fowl without notably injuring the etiological agent associated therewith. The Roentgen ray has little effect on either cells or agent. Fowls manifest two sorts of resistance to the avian tumor, one directed against the implanted tumor cells as such, the other against the action of the etiological agent to cause a neoplastic change. In the individual fowl the two resistances appear to be independent of one another, though they may exist together or may both be absent. A recognition of them will perhaps explain some features in the biology of other tumors.