CELLULAR REACTIONS TO A DYE-PROTEIN WITH A CONCEPT OF THE MECHANISM OF ANTIBODY FORMATION.
1. The use of an antigen which can be seen within cells demonstrates that one may stimulate the phagocytic cells either of the liver and spleen or of the tissues and lymph nodes to produce antibodies. 2. The appearance of antibodies in the serum correlates with the time when the dye-protein is no longer visible within the cells and with the phenomenon of a partial shedding of their surface films. 3. It is thus inferred that the cells of the reticulo-endothelial system normally produce globulin and that antibody globulin represents the synthesis of a new kind of protein under the influence of an antigen. 4. An antigen is a substance which can specifically modify the synthesis of the cytoplasm of the cells of the reticulo-endothelial system.
19 references, click to expand
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THE MOLECULAR WEIGHTS OF ANTIBODIES.Science. 1938 Apr 22;87(2260):372 PMID: 17808590
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THE CELLULAR REACTIONS TO LIPOID FRACTIONS FROM ACID-FAST BACILLI.J Exp Med. 1932 Nov 30;56(6):867-91 PMID: 19870109
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LYMPH NODES AS A SOURCE OF NEUTRALIZING PRINCIPLE FOR VACCINIA.J Exp Med. 1937 Jun 30;66(1):73-100 PMID: 19870650
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CELLULAR REACTIONS TO TUBERCULO-PROTEINS COMPARED WITH THE REACTIONS TO TUBERCULO-LIPIDS.J Exp Med. 1938 Oct 31;68(6):837-52 PMID: 19870821
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THE CHARACTERS OF KUPFFER CELLS LIVING IN VITRO.J Exp Med. 1934 Apr 30;59(5):593-607 PMID: 19870268
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CELLULAR REACTIONS TO WAX-LIKE MATERIALS FROM ACID-FAST BACTERIA : THE UNSAPONIFIABLE FRACTION FROM THE TUBERCLE BACILLUS, STRAIN H-37.J Exp Med. 1935 Nov 30;62(6):751-69 PMID: 19870446
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ELECTROPHORESIS OF PURIFIED ANTIBODY PREPARATIONS.J Exp Med. 1937 Apr 30;65(5):641-6 PMID: 19870623
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ELECTROPHORESIS OF IMMUNE SERUM.Science. 1938 May 6;87(2262):416-7 PMID: 17829941
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THE ACTION OF VITAL STAINS BELONGING TO THE BENZIDINE GROUP.Science. 1914 Mar 27;39(1004):443-54 PMID: 17808671
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THE MOLECULAR WEIGHT OF ANTIBODIES.J Exp Med. 1939 Jan 1;69(1):103-18 PMID: 19870830
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QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : ANTIBODY PRODUCTION IN RABBITS INJECTED WITH AN AZO PROTEIN.J Exp Med. 1933 Jul 31;58(2):137-52 PMID: 19870185
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STUDIES ON THE BLOOD PROTEINS : I. THE SERUM GLOBULINS IN BACTERIAL INFECTION AND IMMUNITY.J Exp Med. 1916 Nov 1;24(5):515-46 PMID: 19868058
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TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : I. TUBERCULIN SENSITIVE TISSUES.J Exp Med. 1936 Aug 31;64(3):339-53 PMID: 19870539
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THE MOLECULAR WEIGHT OF ANTIBODIES.J Exp Med. 1937 Feb 28;65(3):393-414 PMID: 19870608
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QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : THE ROLE OF MULTIPLE REACTIVE GROUPS IN ANTIGEN-ANTIBODY UNION AS ILLUSTRATED BY AN INSTANCE OF CROSS-PRECIPITATION.J Exp Med. 1934 Mar 31;59(4):519-28 PMID: 19870263
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FIBRINOGEN OF THE BLOOD AS INFLUENCED BY THE LIVER NECROSIS OF CHLOROFORM POISONING.J Exp Med. 1911 Jan 5;13(1):136-61 PMID: 19867391
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SPECIAL ARTICLES.Science. 1930 Sep 5;72(1862):252-3 PMID: 17831058
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THE DISTRIBUTION OF THE IMMUNE BODIES OCCURRING IN ANTIPNEUMOCOCCUS SERUM.J Exp Med. 1915 Feb 1;21(2):133-45 PMID: 19867856
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THE PURIFICATION OF THE ANTIBODIES IN TYPE I ANTI-PNEUMOCOCCUS SERUM, AND THE CHEMICAL NATURE OF THE TYPE-SPECIFIC PRECIPITIN REACTION.J Exp Med. 1935 Jul 31;62(2):179-202 PMID: 19870408
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