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PMID: 19853559 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.

Developmental cell ·Vol. 17 ·No. 4 ·2009-10-00 ·Pages 443-58

Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ

Abstract

Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors--including those relevant to the Hedgehog, Wnt, Notch, and TGFbeta pathways--and downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of arrestins in many discrete developmental signaling events suggests an indispensable role for these multifaceted molecular scaffolds.

MeSH Terms
Animals Arrestins/physiology Gene Expression Regulation, Developmental Humans Signal Transduction beta-Arrestins
Chemicals
Arrestins beta-Arrestins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kovacs Jeffrey J
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Hara Makoto R
Davenport Chandra L
Kim Jihee
Lefkowitz Robert J
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Article Info
Journal
Developmental cell
Abbr.
Dev Cell
ISSN
1878-1551
DOI
10.1016/j.devcel.2009.09.011
Published
2009-10-00
Pages
443-58
Language
English
Region
United States
NLM ID
101120028
PMCID
PMC3221601
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NHLBI NIH HHS · HL16037 · United States
NHLBI NIH HHS · R01 HL016037-39 · United States
NHLBI NIH HHS · R01 HL016037 · United States
NHLBI NIH HHS · R01 HL070631 · United States
NHLBI NIH HHS · HL70631 · United States
NHLBI NIH HHS · R01 HL070631-09 · United States
External Links
PubMed source DOI: 10.1016/j.devcel.2009.09.011 PMC Full Text View journal details
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