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PMID: 17506691 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Cilia and developmental signaling.

Annual review of cell and developmental biology ·Vol. 23 ·2007-00-00 ·Pages 345-73

Eggenschwiler JT, Anderson KV

Abstract

Recent studies have revealed unexpected connections between the mammalian Hedgehog (Hh) signal transduction pathway and the primary cilium, a microtubule-based organelle that protrudes from the surface of most vertebrate cells. Intraflagellar transport proteins, which are required for the construction of cilia, are essential for all responses to mammalian Hh proteins, and proteins required for Hh signal transduction are enriched in primary cilia. The phenotypes of different mouse mutants that affect ciliary proteins suggest that cilia may act as processive machines that organize sequential steps in the Hh signal transduction pathway. Cilia on vertebrate cells are likely to be important in additional developmental signaling pathways and are required for PDGF receptor alpha signaling in cultured fibroblasts. Cilia are not essential for either canonical or noncanonical Wnt signaling, although cell-type-specific modulation of cilia components may link cilia and Wnt signaling in some tissues. Because ciliogenesis in invertebrates is limited to a very small number of specialized cell types, the role of cilia in developmental signaling pathways is likely a uniquely vertebrate phenomenon.

MeSH Terms
Animals Body Patterning Cilia/physiology Genetic Diseases, Inborn/metabolism Hedgehog Proteins/metabolism Humans Mice Neural Tube/growth & development Protein Transport/genetics Signal Transduction
Chemicals
Hedgehog Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Eggenschwiler Jonathan T
Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
Anderson Kathryn V
References (130)
130 references, click to expand
  1. Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.
    Differentiation. 2005 Oct;73(8):397-405 PMID: 16316410
  2. Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia.
    Differentiation. 2005 Oct;73(8):425-32 PMID: 16316413
  3. beta-catenin destruction complex: insights and questions from a structural perspective.
    Oncogene. 2006 Dec 4;25(57):7482-91 PMID: 17143292
  4. Intraflagellar transport is essential for endochondral bone formation.
    Development. 2007 Jan;134(2):307-16 PMID: 17166921
  5. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.
    Nature. 2002 Aug 29;418(6901):979-83 PMID: 12198547
  6. Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.
    Science. 2002 Oct 25;298(5594):827-30 PMID: 12215652
  7. Intraflagellar transport.
    Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25 PMID: 12415299
  8. Production of maternal-zygotic mutant zebrafish by germ-line replacement.
    Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14919-24 PMID: 12397179
  9. Developmental roles and clinical significance of hedgehog signaling.
    Curr Top Dev Biol. 2003;53:1-114 PMID: 12509125
  10. The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.
    Development. 2003 May;130(9):1725-34 PMID: 12642479
  11. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.
    Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5286-91 PMID: 12672950
  12. PDGF receptors as cancer drug targets.
    Cancer Cell. 2003 May;3(5):439-43 PMID: 12781361
  13. Two populations of node monocilia initiate left-right asymmetry in the mouse.
    Cell. 2003 Jul 11;114(1):61-73 PMID: 12859898
  14. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm.
    Curr Biol. 2003 Sep 30;13(19):1679-86 PMID: 14521833
  15. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
    Development. 2003 Nov;130(22):5297-305 PMID: 14530294
  16. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
    Nature. 2003 Oct 9;425(6958):628-33 PMID: 14520415
  17. Hedgehog signalling in the mouse requires intraflagellar transport proteins.
    Nature. 2003 Nov 6;426(6962):83-7 PMID: 14603322
  18. Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction.
    Development. 2003 Dec;130(25):6233-43 PMID: 14602680
  19. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.
    Biochem J. 2004 Mar 1;378(Pt 2):353-62 PMID: 14611647
  20. FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.
    Development. 2004 May;131(9):2149-59 PMID: 15105374
  21. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.
    Nat Genet. 2004 May;36(5):462-70 PMID: 15107855
  22. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis.
    Cell. 2004 May 14;117(4):527-39 PMID: 15137945
  23. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
    Cell. 2004 May 14;117(4):541-52 PMID: 15137946
  24. The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling.
    Development. 2004 Jun;131(11):2521-32 PMID: 15115751
  25. Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons.
    Neuron. 2004 Jun 10;42(5):703-16 PMID: 15182712
  26. The Hedgehog response network: sensors, switches, and routers.
    Science. 2004 Jun 18;304(5678):1755-9 PMID: 15205520
  27. Frizzled6 controls hair patterning in mice.
    Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9277-81 PMID: 15169958
  28. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.
    Development. 2004 Jul;131(14):3457-67 PMID: 15226261
  29. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo.
    Genes Dev. 2004 Jul 1;18(13):1565-76 PMID: 15198976
  30. Polycystins and mechanosensation in renal and nodal cilia.
    Bioessays. 2004 Aug;26(8):844-56 PMID: 15273987
  31. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.
    Development. 2004 Aug;131(16):4085-93 PMID: 15269167
  32. Polarity proteins control ciliogenesis via kinesin motor interactions.
    Curr Biol. 2004 Aug 24;14(16):1451-61 PMID: 15324661
  33. OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis.
    J Am Soc Nephrol. 2004 Oct;15(10):2556-68 PMID: 15466260
  34. Cilia-related diseases.
    J Pathol. 2004 Nov;204(4):470-7 PMID: 15495266
  35. Evidence of congenitally nonfunctioning cilia in the tracheobronchial tract in two subjects.
    Am Rev Respir Dis. 1975 Dec;112(6):807-9 PMID: 1081860
  36. A human syndrome caused by immotile cilia.
    Science. 1976 Jul 23;193(4250):317-9 PMID: 1084576
  37. Phagokinetic tracks of 3T3 cells: parallels between the orientation of track segments and of cellular structures which contain actin or tubulin.
    Cell. 1977 Oct;12(2):333-9 PMID: 334371
  38. Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons.
    J Cell Biol. 1998 May 18;141(4):993-1008 PMID: 9585417
  39. Platelet-derived growth factor induces chemotaxis of neuroepithelial stem cells.
    J Neurosci Res. 1998 Sep 1;53(5):521-30 PMID: 9726423
  40. Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects.
    J Cell Biol. 1998 Dec 14;143(6):1591-601 PMID: 9852153
  41. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.
    Cell. 1998 Dec 11;95(6):829-37 PMID: 9865700
  42. Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.
    Genes Dev. 1999 Mar 15;13(6):709-17 PMID: 10090727
  43. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.
    Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5043-8 PMID: 10220415
  44. Movement of motor and cargo along cilia.
    Nature. 1999 Apr 22;398(6729):674 PMID: 10227290
  45. Dynamic association of proteasomal machinery with the centrosome.
    J Cell Biol. 1999 May 3;145(3):481-90 PMID: 10225950
  46. Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors.
    Development. 1999 Jun;126(11):2419-29 PMID: 10226001
  47. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis.
    J Cell Biol. 1999 May 17;145(4):825-36 PMID: 10330409
  48. Requirement for Wnt3 in vertebrate axis formation.
    Nat Genet. 1999 Aug;22(4):361-5 PMID: 10431240
  49. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.
    Genes Dev. 1999 Aug 15;13(16):2072-86 PMID: 10465785
  50. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.
    Development. 1999 Oct;126(20):4557-68 PMID: 10498690
  51. Mechanism of action and in vivo role of platelet-derived growth factor.
    Physiol Rev. 1999 Oct;79(4):1283-316 PMID: 10508235
  52. Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin.
    Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16588-93 PMID: 15539463
  53. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
    J Am Soc Nephrol. 2004 Dec;15(12):3035-43 PMID: 15579506
  54. MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis.
    J Cell Sci. 2005 Mar 1;118(Pt 5):1007-20 PMID: 15731008
  55. Compartmentalization of growth factor receptor signalling.
    Curr Opin Cell Biol. 2005 Apr;17(2):107-11 PMID: 15780584
  56. Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes.
    Diabetes. 2005 May;54(5):1581-7 PMID: 15855349
  57. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.
    Nat Genet. 2005 May;37(5):537-43 PMID: 15852005
  58. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors.
    Development. 2005 Jul;132(13):3103-11 PMID: 15930098
  59. Functional coordination of intraflagellar transport motors.
    Nature. 2005 Jul 28;436(7050):583-7 PMID: 16049494
  60. De novo formation of left-right asymmetry by posterior tilt of nodal cilia.
    PLoS Biol. 2005 Aug;3(8):e268 PMID: 16035921
  61. Cilia and Hedgehog responsiveness in the mouse.
    Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11325-30 PMID: 16061793
  62. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.
    Nat Genet. 2005 Oct;37(10):1135-40 PMID: 16170314
  63. Vertebrate Smoothened functions at the primary cilium.
    Nature. 2005 Oct 13;437(7061):1018-21 PMID: 16136078
  64. PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts.
    Curr Biol. 2005 Oct 25;15(20):1861-6 PMID: 16243034
  65. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.
    PLoS Genet. 2005 Oct;1(4):e53 PMID: 16254602
  66. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.
    Dev Biol. 2005 Nov 15;287(2):378-89 PMID: 16229832
  67. The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation.
    Hum Mol Genet. 2007 Jan 15;16(2):173-86 PMID: 17185389
  68. Tissue/planar cell polarity in vertebrates: new insights and new questions.
    Development. 2007 Feb;134(4):647-58 PMID: 17259302
  69. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates.
    Development. 2006 Jan;133(1):3-14 PMID: 16339192
  70. Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification.
    Nat Genet. 2006 Jan;38(1):112-7 PMID: 16311594
  71. Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing.
    Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):33-8 PMID: 16371461
  72. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.
    Development. 2006 Feb;133(3):569-78 PMID: 16396903
  73. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.
    Dev Cell. 2006 Feb;10(2):187-97 PMID: 16459298
  74. Making digit patterns in the vertebrate limb.
    Nat Rev Mol Cell Biol. 2006 Jan;7(1):45-53 PMID: 16493412
  75. Polygenic control of Caenorhabditis elegans fat storage.
    Nat Genet. 2006 Mar;38(3):363-8 PMID: 16462744
  76. Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling.
    Nat Genet. 2006 Mar;38(3):303-11 PMID: 16493421
  77. Dissecting the molecular mechanisms of intraflagellar transport in chlamydomonas.
    Curr Biol. 2006 Mar 7;16(5):450-9 PMID: 16527740
  78. Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.
    Mol Cell Biol. 2006 May;26(9):3365-77 PMID: 16611981
  79. Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.
    J Neurosci. 2006 May 10;26(19):5265-75 PMID: 16687519
  80. The left-right axis in the mouse: from origin to morphology.
    Development. 2006 Jun;133(11):2095-104 PMID: 16672339
  81. Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.
    Mol Cell Biol. 2006 Jun;26(11):4316-26 PMID: 16705181
  82. oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo.
    Curr Biol. 2006 May 23;16(10):945-57 PMID: 16713951
  83. X-inactivation and human disease: X-linked dominant male-lethal disorders.
    Curr Opin Genet Dev. 2006 Jun;16(3):254-9 PMID: 16650755
  84. Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries.
    Development. 1999 Dec;126(23):5495-504 PMID: 10556073
  85. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.
    Nat Cell Biol. 1999 Sep;1(5):312-9 PMID: 10559945
  86. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.
    Cell. 2000 Feb 18;100(4):423-34 PMID: 10693759
  87. The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.
    Development. 2000 Jun;127(11):2347-55 PMID: 10804177
  88. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain.
    Brain Res. 2000 Jul 28;872(1-2):271-5 PMID: 10924708
  89. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.
    Development. 2000 Sep;127(18):4001-10 PMID: 10952898
  90. Hypothalamic dopamine and serotonin in the regulation of food intake.
    Nutrition. 2000 Oct;16(10):843-57 PMID: 11054589
  91. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.
    J Cell Biol. 2000 Oct 30;151(3):709-18 PMID: 11062270
  92. G-protein signaling through tubby proteins.
    Science. 2001 Jun 15;292(5524):2041-50 PMID: 11375483
  93. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.
    Nature. 2001 Jul 12;412(6843):194-8 PMID: 11449277
  94. A role for the Tubby-like protein 1 in rhodopsin transport.
    Invest Ophthalmol Vis Sci. 2001 Aug;42(9):1955-62 PMID: 11481257
  95. Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene.
    Oncogene. 2001 Sep 20;20(42):5972-81 PMID: 11593404
  96. Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.
    Genesis. 2001 Oct;31(2):72-7 PMID: 11668681
  97. The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly.
    Curr Biol. 2001 Oct 16;11(20):1591-4 PMID: 11676919
  98. Hedgehog signaling in animal development: paradigms and principles.
    Genes Dev. 2001 Dec 1;15(23):3059-87 PMID: 11731473
  99. An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.
    Dev Cell. 2002 Jan;2(1):103-13 PMID: 11782318
  100. Planar signaling and morphogenesis in Drosophila.
    Dev Cell. 2002 May;2(5):525-35 PMID: 12015961
  101. Dual control of cell growth by somatomedins and platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1979 Mar;76(3):1279-83 PMID: 312500
  102. Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells.
    Cell. 1979 Jul;17(3):527-35 PMID: 476831
  103. Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40.
    Cell. 1979 Dec;18(4):1065-72 PMID: 229969
  104. Platelet-derived growth factor-modulated proteins: constitutive synthesis by a transformed cell line.
    Proc Natl Acad Sci U S A. 1981 Jul;78(7):4358-62 PMID: 6170062
  105. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.
    Nature. 1984 Oct 4-10;311(5985):433-8 PMID: 6090941
  106. Mutant sensory cilia in the nematode Caenorhabditis elegans.
    Dev Biol. 1986 Oct;117(2):456-87 PMID: 2428682
  107. A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.
    Nat Genet. 1993 Mar;3(3):241-6 PMID: 8387379
  108. A motility in the eukaryotic flagellum unrelated to flagellar beating.
    Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5519-23 PMID: 8516294
  109. The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein.
    J Cell Biol. 1994 Jul;126(1):175-88 PMID: 8027176
  110. The alpha PDGFR tyrosine kinase mediates locomotion of two different cell types through chemotaxis and chemokinesis.
    Biochem Biophys Res Commun. 1994 Oct 28;204(2):628-34 PMID: 7980524
  111. Cochlear and retinal degeneration in the tubby mouse.
    Neuroreport. 1995 Apr 19;6(6):845-9 PMID: 7612867
  112. Flagellar assembly in two hundred and fifty easy-to-follow steps.
    Trends Genet. 1995 Oct;11(10):398-404 PMID: 7482766
  113. The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane.
    J Cell Biol. 1995 Dec;131(6 Pt 1):1517-27 PMID: 8522608
  114. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.
    Cell. 1996 Jun 14;85(6):863-73 PMID: 8681381
  115. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
    Nature. 1996 Oct 3;383(6599):407-13 PMID: 8837770
  116. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
    Development. 1997 Jan;124(1):113-23 PMID: 9006072
  117. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites.
    Development. 1997 Jul;124(14):2691-700 PMID: 9226440
  118. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
    Cell. 1997 Jul 11;90(1):181-92 PMID: 9230313
  119. Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.
    PLoS Genet. 2005 Dec;1(6):e64 PMID: 16327884
  120. An early role for sonic hedgehog from foregut endoderm in jaw development: ensuring neural crest cell survival.
    Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11607-12 PMID: 16868080
  121. The primary cilium as the cell's antenna: signaling at a sensory organelle.
    Science. 2006 Aug 4;313(5787):629-33 PMID: 16888132
  122. Disruption of early proximodistal patterning and AVE formation in Apc mutants.
    Development. 2006 Sep;133(17):3379-87 PMID: 16887818
  123. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly.
    Mol Biol Cell. 2006 Sep;17(9):3781-92 PMID: 16775004
  124. Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube.
    Dev Cell. 2006 Sep;11(3):325-37 PMID: 16950124
  125. Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors.
    J Cell Biol. 2006 Sep 25;174(7):1035-45 PMID: 17000880
  126. Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport.
    Cell Mol Life Sci. 2006 Sep;63(18):2145-61 PMID: 16909204
  127. Endocytosis, endosome trafficking, and the regulation of Drosophila development.
    Annu Rev Cell Dev Biol. 2006;22:181-206 PMID: 16776558
  128. The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.
    Mol Biol Cell. 2006 Dec;17(12):5053-62 PMID: 17021254
  129. The ciliopathies: an emerging class of human genetic disorders.
    Annu Rev Genomics Hum Genet. 2006;7:125-48 PMID: 16722803
  130. Targeting the Hedgehog pathway in cancer.
    Nat Rev Drug Discov. 2006 Dec;5(12):1026-33 PMID: 17139287
Article Info
Journal
Annual review of cell and developmental biology
Abbr.
Annu Rev Cell Dev Biol
ISSN
1081-0706
DOI
10.1146/annurev.cellbio.23.090506.123249
Published
2007-00-00
Pages
345-73
Language
English
Region
United States
NLM ID
9600627
PMCID
PMC2094042
Subset
IM
Grants
NICHD NIH HHS · R01 HD050761 · United States
NICHD NIH HHS · R01 HD050761-01 · United States
NICHD NIH HHS · R01 HD050761-02 · United States
External Links
PubMed source DOI: 10.1146/annurev.cellbio.23.090506.123249 PMC Full Text View journal details
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