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PMID: 19843852 Published · ppublish English Journal Article Review

Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.

Cancer research ·Vol. 69 ·No. 21 ·2009-11-01 ·Pages 8223-30

Weissman B, Knudsen KE

Abstract

There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10 to 12 unique subunits. Although the biochemical consequence of SWI/SNF in model systems has been extensively reviewed, the present article focuses on the evidence linking SWI/SNF perturbations to cancer initiation and tumor progression in human disease.

MeSH Terms
Animals Chromatin/metabolism Chromosomal Proteins, Non-Histone/metabolism Humans Neoplasms/metabolism Transcription Factors/metabolism
Chemicals
Chromatin Chromosomal Proteins, Non-Histone SWI-SNF-B chromatin-remodeling complex Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Weissman Bernard
Department of Pathology and Laboratory and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Knudsen Karen E
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Article Info
Journal
Cancer research
Abbr.
Cancer Res
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-09-2166
Published
2009-11-01
Epub
2009-00-20
Pages
8223-30
Language
English
Region
United States
NLM ID
2984705R
PMCID
PMC3272668
Subset
IM
Grants
NCI NIH HHS · R01 CA116777 · United States
NCI NIH HHS · R01 CA116777-05 · United States
NIEHS NIH HHS · R01 ES016675 · United States
NIEHS NIH HHS · R01 ES016675-10 · United States
External Links
PubMed source DOI: 10.1158/0008-5472.CAN-09-2166 PMC Full Text View journal details
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