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PMID: 8071970 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

Journal of medical genetics ·Vol. 31 ·No. 6 ·1994-06-00 ·Pages 448-52

Teare MD, Rohde K, Santibáñez Koref MF

Abstract

A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.

MeSH Terms
Alleles Breast Neoplasms/genetics Female Gene Deletion Genes, Tumor Suppressor Genes, p53 Genetic Linkage Heterozygote Humans Li-Fraumeni Syndrome/genetics Male Models, Genetic Neoplastic Syndromes, Hereditary/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Teare M D
Cancer Research Campaign, Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.
Rohde K
Santibáñez Koref M F
References (10)
10 references, click to expand
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Article Info
Journal
Journal of medical genetics
Abbr.
J Med Genet
ISSN
0022-2593
DOI
10.1136/jmg.31.6.448
Published
1994-06-00
Pages
448-52
Language
English
Region
England
NLM ID
2985087R
PMCID
PMC1049921
Subset
IM
External Links
PubMed source DOI: 10.1136/jmg.31.6.448 PMC Full Text View journal details
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