It takes two to tango to the melanosome.

The Journal of cell biology ·Vol. 187 ·No. 2 ·2009-10-19 ·Pages 161-3

Lakkaraju A, Carvajal-Gonzalez JM, Rodriguez-Boulan E

Abstract

The role of clathrin adaptor proteins in sorting cargo in the biosynthetic and recycling routes is an area of intense research. In this issue, Delevoye et al. (2009. J. Cell Biol. doi:10.1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis.

MeSH Terms

Adaptor Protein Complex 1/genetics,metabolism Animals Endosomes/metabolism Humans Kinesins/genetics,metabolism Melanosomes/metabolism

Chemicals

Adaptor Protein Complex 1 KIF13A protein, human Kinesins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lakkaraju Aparna

Margaret M. Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, NY 10065, USA.

Carvajal-Gonzalez Jose Maria

Rodriguez-Boulan Enrique

References (14)

14 references, click to expand

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Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

1540-8140

DOI

10.1083/jcb.200909100

Published

2009-10-19

Pages

161-3

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2768836

Subset

Grants

NIGMS NIH HHS · R01 GM034107 · United States

Corrections

CommentOn

PMID: 19841138

External Links

PubMed source DOI: 10.1083/jcb.200909100 PMC Full Text View journal details

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