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PMID: 19836265 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.

Immunity ·Vol. 31 ·No. 5 ·2009-11-20 ·Pages 711-21

Ransohoff RM

Abstract

There are several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobiology. This review limns several illustrative examples and presents general principles of chemokine action that are manifest in both systems. These include the following: (1) chemokines tend equally to arrest cells and to make them move, in the process of positioning target cells with spatiotemporal precision; (2) signaling and nonsignaling receptors collaborate to adjust the chemokine environment for maximal efficacy; and (3) expression of a single chemokine receptor on circulating blood cells and parenchymal cells is often used to coordinate complex tissue responses. The challenge is to integrate knowledge of the roles of key receptors (as well as their ligands) into a coherent account of events during pathologic processes, in order to guide therapeutic development.

MeSH Terms
Animals Chemokines/metabolism Humans Immune System Neurobiology Receptors, Chemokine/metabolism
Chemicals
Chemokines Receptors, Chemokine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ransohoff Richard M
Neuroinflammation Research Center (Lerner Research Institute) and Mellen Center for MS Treatment and Research (Neurological Institute), Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA. ransohr@ccf.org
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2009.09.010
Email
ransohr@ccf.org
Published
2009-11-20
Pages
711-21
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC2787682
Subset
IM
Grants
NINDS NIH HHS · K24 NS051400-04 · United States
NINDS NIH HHS · R01 NS032151-14A1 · United States
NINDS NIH HHS · R01 NS041972-06 · United States
NINDS NIH HHS · P50 NS038667 · United States
NINDS NIH HHS · R01 NS032151 · United States
FIC NIH HHS · R03 TW000784-03 · United States
NINDS NIH HHS · K24 NS051400 · United States
NINDS NIH HHS · R01 NS041972 · United States
NINDS NIH HHS · P50 NS038667-10 · United States
External Links
PubMed source DOI: 10.1016/j.immuni.2009.09.010 PMC Full Text View journal details
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