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PMID: 9852583 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 18 ·No. 24 ·1998-12-15 ·Pages 10457-63

Robinson S, Tani M, Strieter RM, Ransohoff RM, Miller RH

Abstract

Chemokines, (chemotactic cytokines) are a family of regulatory molecules involved in modulating inflammatory responses. Here we demonstrate that the chemokine growth-regulated oncogene-alpha (GRO-alpha) is a potent promoter of oligodendrocyte precursor proliferation. The proliferative response of immature spinal cord oligodendrocyte precursors to their major mitogen, platelet derived growth factor (PDGF), is dramatically enhanced by GRO-alpha present in spinal cord conditioned medium. One source of GRO-alpha is a subset of spinal cord astrocytes. Cultures of astrocytes contain GRO-alpha mRNA and protein and secrete biologically active concentrations of GRO-alpha. In postnatal spinal cord white matter the location of GRO-alpha-immunoreactive cells is developmentally regulated: GRO-alpha+ cells first appear in ventral and later in dorsal spinal cord white matter. These results suggest that localized proliferation of oligodendrocytes is mediated by synergy between PDGF and GRO-alpha.

MeSH Terms
Animals Astrocytes/chemistry,metabolism Cell Division/drug effects Cells, Cultured Chemokine CXCL1 Chemokines, CXC/metabolism,pharmacology Chemotactic Factors/metabolism,pharmacology Culture Media, Conditioned/pharmacology Dose-Response Relationship, Drug Drug Synergism Gangliosides/analysis Gene Expression Regulation, Developmental Growth Substances/metabolism,pharmacology Intercellular Signaling Peptides and Proteins Oligodendroglia/cytology,drug effects Platelet-Derived Growth Factor/pharmacology RNA, Messenger/analysis Rats Spinal Cord/cytology Stem Cells/cytology,drug effects
Chemicals
Chemokine CXCL1 Chemokines, CXC Chemotactic Factors Culture Media, Conditioned Cxcl1 protein, rat Gangliosides Growth Substances Intercellular Signaling Peptides and Proteins Platelet-Derived Growth Factor RNA, Messenger ganglioside A2B5
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Robinson S
Department of Neurosurgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Tani M
Strieter R M
Ransohoff R M
Miller R H
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1998-12-15
Pages
10457-63
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6793357
Subset
IM
Grants
NINDS NIH HHS · R01 NS036674 · United States
NINDS NIH HHS · R37 NS036674 · United States
NINDS NIH HHS · NS 36674 · United States
External Links
PubMed source PMC Full Text View journal details
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