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PMID: 1976821 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes.

Journal of virology ·Vol. 64 ·No. 11 ·1990-11-00 ·Pages 5457-64

Jonjić S, Pavić I, Lucin P, Rukavina D, Koszinowski UH

Abstract

Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain conditions the CD8+ T-lymphocyte subset can be dispensable for clearance of cytomegalovirus. Mice depleted of the CD8+ T-lymphocyte subset eliminated infectious virus with a clearance kinetics similar to that of normal mice. Adoptive transfer studies revealed that the limitation of virus spread required the cooperation between the CD4+ subset and other cells. Comparison between protective functions generated in fully immunocompetent and in CD8- mice demonstrated that elimination of the CD8+ subset before infection altered the quality of the antiviral immune response. The compensatory protective activity gained by CD4+ cells in CD8- mice was absent in normal mice recovering from virus infection.

MeSH Terms
Animals Antigens, Differentiation, T-Lymphocyte/analysis Antigens, Viral/immunology CD4-Positive T-Lymphocytes/immunology CD8 Antigens Cytomegalovirus/immunology Cytomegalovirus Infections/immunology Cytotoxicity, Immunologic Immunity, Cellular Mice Mice, Inbred BALB C Skin Transplantation/immunology T-Lymphocyte Subsets/immunology T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antigens, Differentiation, T-Lymphocyte Antigens, Viral CD8 Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jonjić S
Department of Physiology and Immunology, Faculty of Medicine, University of Rijeka, Yugoslavia.
Pavić I
Lucin P
Rukavina D
Koszinowski U H
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.11.5457-5464.1990
Published
1990-11-00
Pages
5457-64
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC248597
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.64.11.5457-5464.1990 PMC Full Text View journal details
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