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PMID: 3023703 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Modification of acute murine cytomegalovirus adrenal gland infection by adoptive spleen cell transfer.

Journal of virology ·Vol. 61 ·No. 1 ·1987-01-00 ·Pages 23-8

Shanley JD

Abstract

Homozygous (nu/nu), athymic nude mice, infected with murine cytomegalovirus (MCMV), develop unremitting and ablative virus infection involving both the adrenal cortex and medulla. During acute infection, adoptive transfer of MCMV-immune, but not naive, spleen cells suppressed virus replication in the adrenal glands, but not the lungs or salivary gland. T lymphocytes, not macrophages or B cells, were responsible for limiting viral replication. The effect by donor cells was restricted by compatibility at the major histocompatibility locus. Restriction of MCMV replication in the adrenal gland was associated with T lymphocytes of the L3T4 phenotype. Thus, T-cell immunity is critical in regulating MCMV replication in the adrenal glands, and T lymphocytes restricted by class II major histocompatibility antigens mediate this effect.

MeSH Terms
Adrenal Gland Diseases/immunology,microbiology Animals B-Lymphocytes/classification,immunology Cytomegalovirus Infections/immunology Female Immunization, Passive Male Mice Mice, Inbred BALB C Mice, Nude T-Lymphocytes/classification,immunology,transplantation
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Shanley J D
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34 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.1.23-28.1987
Published
1987-01-00
Pages
23-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255192
Subset
IM
Grants
NHLBI NIH HHS · HL/AI 34813-01A1 · United States
External Links
PubMed source DOI: 10.1128/JVI.61.1.23-28.1987 PMC Full Text View journal details
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