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PMID: 19763524 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Post-translationally modified T cell epitopes: immune recognition and immunotherapy.

Journal of molecular medicine (Berlin, Germany) ·Vol. 87 ·No. 11 ·2009-11-00 ·Pages 1045-51

Petersen J, Purcell AW, Rossjohn J

Abstract

The functionality of proteins is greatly extended by a diverse array of post-translational modifications (PTMs), many of which are recognized by the immune system. Notably, a significant proportion of peptides presented to T cells by the major histocompatibility complex in vivo are post-translationally modified. Since the cellular mechanisms that introduce and control protein modifications can differ between health and disease, the associated changes in antigen presentation have the potential to alter immune responses. A number of such situations have been implicated with infection, inflammation, autoimmune disease, and cancer, and the investigation of PTMs that affect antigen recognition has provided insight in disease progression as well as raising prospects for novel approaches in immunotherapy.

MeSH Terms
Animals Epitopes, T-Lymphocyte/immunology,metabolism Humans Immunotherapy/trends Major Histocompatibility Complex Protein Processing, Post-Translational
Chemicals
Epitopes, T-Lymphocyte
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Petersen Jan
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.
Purcell Anthony W
Rossjohn Jamie
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Article Info
Journal
Journal of molecular medicine (Berlin, Germany)
Abbr.
J Mol Med (Berl)
ISSN
1432-1440
DOI
10.1007/s00109-009-0526-4
Published
2009-11-00
Epub
2009-00-08
Pages
1045-51
Language
English
Region
Germany
NLM ID
9504370
Subset
IM
Grants
NIGMS NIH HHS · GM057428-06 · United States
External Links
PubMed source DOI: 10.1007/s00109-009-0526-4 View journal details
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