Decoding Tat: the biology of HIV Tat posttranslational modifications.

Microbes and infection ·Vol. 7 ·No. 13 ·2005-10-00 ·Pages 1364-9

Hetzer C, Dormeyer W, Schnölzer M, Ott M

Abstract

The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed.

MeSH Terms

Arginine/metabolism Gene Products, tat/metabolism HIV-1/enzymology,metabolism Humans Protein Processing, Post-Translational tat Gene Products, Human Immunodeficiency Virus

Chemicals

Gene Products, tat tat Gene Products, Human Immunodeficiency Virus Arginine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hetzer Claudia

Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

Dormeyer Wilma

Schnölzer Martina

Ott Melanie

Article Info

Journal

Microbes and infection

Abbr.

Microbes Infect

ISSN

1286-4579

DOI

10.1016/j.micinf.2005.06.003

Published

2005-10-00

Epub

2005-00-24

Pages

1364-9

Language

English

Region

France

NLM ID

100883508

Subset

External Links

PubMed source DOI: 10.1016/j.micinf.2005.06.003 View journal details

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Decoding Tat: the biology of HIV Tat posttranslational modifications.

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