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PMID: 1976101 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping.

Diabetologia ·Vol. 33 ·No. 7 ·1990-07-00 ·Pages 387-95

Jenkins D, Mijovic C, Fletcher J, Jacobs KH, Bradwell AR, Barnett AH

Abstract

A major component of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus has been mapped to the major histocompatibility complex. Certain gene alleles in this region determine susceptibility and resistance to the disease. Mapping of susceptibility is hindered by the limitations of conventional tissue typing techniques, and by strong linkage disequilibrium within this part of the genome. Recombinant DNA technology and trans-racial studies have been used to allow finer mapping of genetic predisposition to Type 1 diabetes. These techniques have localised alleles encoding susceptibility and resistance to the DQ region. Other alleles determining disease susceptibility remain poorly localised.

MeSH Terms
Diabetes Mellitus, Type 1/genetics,immunology Genetic Predisposition to Disease Humans Major Histocompatibility Complex Polymorphism, Restriction Fragment Length Racial Groups/genetics
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Jenkins D
Department of Medicine, University of Birmingham, U.K.
Mijovic C
Fletcher J
Jacobs K H
Bradwell A R
Barnett A H
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00404086
Published
1990-07-00
Pages
387-95
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1007/BF00404086 View journal details
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