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PMID: 19760644 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Keeping an eye on retinoblastoma control of human embryonic stem cells.

Journal of cellular biochemistry ·Vol. 108 ·No. 5 ·2009-12-01 ·Pages 1023-30

Conklin JF, Sage J

Abstract

Human embryonic stem cells (hESCs) hold great promise in regenerative medicine. However, before the full potential of these cells is achieved, major basic biological questions need to be addressed. In particular, there are still gaps in our knowledge of the molecular mechanisms underlying the derivation of hESCs from blastocysts, the regulation of the undifferentiated, pluripotent state, and the control of differentiation into specific lineages. Furthermore, we still do not fully understand the tumorigenic potential of hESCs, limiting their use in regenerative medicine. The RB pathway is a key signaling module that controls cellular proliferation, cell survival, chromatin structure, and cellular differentiation in mammalian cells. Members of the RB pathway are important regulators of hESC biology and manipulation of the activity of this pathway may provide novel means to control the fate of hESCs. Here we review what is known about the expression and function of members of the RB pathway in hESCs and discuss areas of interest in this field.

MeSH Terms
Animals Blastocyst/cytology,physiology Cell Cycle/genetics Cell Cycle Proteins/genetics,metabolism Cell Differentiation/genetics Cell Lineage Cell Proliferation Cell Survival Cell Transformation, Neoplastic Chromatin Embryonic Stem Cells/cytology,physiology Forecasting Genes, Retinoblastoma Humans Mice Pluripotent Stem Cells/pathology,physiology Regenerative Medicine/trends Signal Transduction Species Specificity Transcription Factors/genetics,metabolism
Chemicals
Cell Cycle Proteins Chromatin Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Conklin Jamie F
Department of Pediatrics, Stanford Medical School, Stanford, California 94305, USA.
Sage Julien
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Article Info
Journal
Journal of cellular biochemistry
Abbr.
J Cell Biochem
ISSN
1097-4644
DOI
10.1002/jcb.22342
Published
2009-12-01
Pages
1023-30
Language
English
Region
United States
NLM ID
8205768
PMCID
PMC2945208
Subset
IM
Grants
NIGMS NIH HHS · T32 GM007790-33 · United States
External Links
PubMed source DOI: 10.1002/jcb.22342 PMC Full Text View journal details
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