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PMID: 19741703 Published · ppublish English Journal Article Review

Molecular networks as sensors and drivers of common human diseases.

Nature ·Vol. 461 ·No. 7261 ·2009-09-10 ·Pages 218-23

Schadt EE

Abstract

The molecular biology revolution led to an intense focus on the study of interactions between DNA, RNA and protein biosynthesis in order to develop a more comprehensive understanding of the cell. One consequence of this focus was a reduced attention to whole-system physiology, making it difficult to link molecular biology to clinical medicine. Equipped with the tools emerging from the genomics revolution, we are now in a position to link molecular states to physiological ones through the reverse engineering of molecular networks that sense DNA and environmental perturbations and, as a result, drive variations in physiological states associated with disease.

MeSH Terms
Animals Disease/genetics Gene Regulatory Networks Genome-Wide Association Study Genomics Humans Metabolic Networks and Pathways Molecular Biology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Schadt Eric E
Pacific Biosciences, 1505 Adams Drive, Menlo Park, California 94025, USA. eschadt@pacificbiosciences.com
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature08454
Email
eschadt@pacificbiosciences.com
Published
2009-09-10
Pages
218-23
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/nature08454 View journal details
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