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PMID: 19699678 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Review

Alarmins link neutrophils and dendritic cells.

Trends in immunology ·Vol. 30 ·No. 11 ·2009-11-00 ·Pages 531-7

Yang D, de la Rosa G, Tewary P, Oppenheim JJ

Abstract

Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues and are crucial for initiating host innate defense and adaptive immunity. Although the contribution of neutrophils to innate immune defense is mediated predominantly by phagocytosis and killing of microorganisms, neutrophils also participate in the induction of adaptive immune responses. At sites of infection and/or injury, neutrophils release numerous mediators upon degranulation or death, among these are alarmins which have a characteristic dual capacity to mobilize and activate antigen-presenting cells. We describe here how alarmins released by neutrophil degranulation and/or death can link neutrophils to dendritic cells by promoting their recruitment and activation, resulting in the augmentation of innate and adaptive immune responses.

MeSH Terms
Adaptive Immunity Animals Antimicrobial Cationic Peptides/metabolism Cell Communication/immunology Cell Degranulation Cytokines/metabolism Defensins/metabolism Dendritic Cells/immunology,metabolism HMGB1 Protein/metabolism Humans Immunity, Innate Lactoferrin/metabolism Neutrophils/immunology,metabolism
Chemicals
Antimicrobial Cationic Peptides Cytokines Defensins HMGB1 Protein ropocamptide Lactoferrin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yang De
Basic Science Program, SAIC-Frederick, Inc., Frederick, Maryland 21702-1201, United States.
de la Rosa Gonzalo
Tewary Poonam
Oppenheim Joost J
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Article Info
Journal
Trends in immunology
Abbr.
Trends Immunol
ISSN
1471-4981
DOI
10.1016/j.it.2009.07.004
Published
2009-11-00
Epub
2009-00-21
Pages
531-7
Language
English
Region
England
NLM ID
100966032
PMCID
PMC2767430
Subset
IM
Grants
NCI NIH HHS · N01CO12400 · United States
Intramural NIH HHS · Z01 BC009369-17 · United States
NCI NIH HHS · N01-CO-12400 · United States
External Links
PubMed source DOI: 10.1016/j.it.2009.07.004 PMC Full Text View journal details
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