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PMID: 19692989 Published · ppublish English Journal Article Review

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development.

Nature immunology ·Vol. 10 ·No. 9 ·2009-09-00 ·Pages 929-32

O'Garra A, Murphy KM

Abstract

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

MeSH Terms
Animals Antigen-Presenting Cells/physiology Cell Differentiation Cell Polarity Humans Interferon-gamma/biosynthesis Interleukin-10/physiology Interleukin-12/physiology Macrophages/physiology Th1 Cells/physiology Th2 Cells/physiology
Chemicals
Interleukin-10 Interleukin-12 Interferon-gamma
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
O'Garra Anne
Division of Immunoregulation, The Medical Research Council National Institute for Medical Research, London, UK. aogarra@nimr.mrc.ac.uk
Murphy Kenneth M
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni0909-929
Email
aogarra@nimr.mrc.ac.uk
Published
2009-09-00
Pages
929-32
Language
English
Region
United States
NLM ID
100941354
Subset
IM
Grants
Medical Research Council · MC_U117565642 · United Kingdom
External Links
PubMed source DOI: 10.1038/ni0909-929 View journal details
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