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PMID: 19687189 Published · ppublish English Journal Article

Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds.

Evidence-based complementary and alternative medicine : eCAM ·Vol. 2011 ·2011-00-00 ·Pages 212641

Geethangili M, Tzeng YM

Abstract

Antrodia camphorata is a unique mushroom of Taiwan, which has been used as a traditional medicine for protection of diverse health-related conditions. In an effort to translate this Eastern medicine into Western-accepted therapy, a great deal of work has been carried out on A. camphorata. This review discusses the biological activities of the crude extracts and the main bioactive compounds of A. camphorata. The list of bioactivities of crude extracts is huge, ranging from anti-cancer to vasorelaxation and others. Over 78 compounds consisting of terpenoids, benzenoids, lignans, benzoquinone derivatives, succinic and maleic derivatives, in addition to polysaccharides have been identified. Many of these compounds were evaluated for biological activity. Many activities of crude extracts and pure compounds of A. camphorata against some major diseases of our time, and thus, a current review is of great importance. It is concluded that A. camphorata can be considered as an efficient alternative phytotherapeutic agent or a synergizer in the treatment of cancer and other immune-related diseases. However, clinical trails of human on A. camphorata extracts are limited and those of pure compounds are absent. The next step is to produce some medicines from A. camphorata, however, the production may be hampered by problems related to mass production.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Geethangili Madamanchi
Institute of Biochemical Sciences and Technology, Chaoyang University of Technology, Wufeng, Taiwan.
Tzeng Yew-Min
References (74)
74 references, click to expand
  1. Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells.
    Food Chem Toxicol. 2006 Aug;44(8):1316-26 PMID: 16600460
  2. Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata.
    Planta Med. 2004 Apr;70(4):310-4 PMID: 15095145
  3. Chemical characterization and anti-inflammatory effect of polysaccharides fractionated from submerge-cultured Antrodia camphorata mycelia.
    J Agric Food Chem. 2007 Jun 27;55(13):5007-12 PMID: 17536816
  4. Protective effects of a neutral polysaccharide isolated from the mycelium of Antrodia cinnamomea on Propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice.
    Chem Pharm Bull (Tokyo). 2006 Apr;54(4):496-500 PMID: 16595952
  5. Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.
    Cancer Lett. 2005 Apr 18;221(1):77-89 PMID: 15797630
  6. Antioxidative and hepatoprotective effects of Antrodia camphorata extract.
    J Agric Food Chem. 2003 May 21;51(11):3302-8 PMID: 12744658
  7. Characterization and functional study of Antrodia camphorata lipopolysaccharide.
    J Agric Food Chem. 2005 Jan 26;53(2):469-74 PMID: 15656690
  8. Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo.
    Food Chem Toxicol. 2008 Aug;46(8):2680-8 PMID: 18550246
  9. Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells.
    Nutr Cancer. 2004;48(2):189-97 PMID: 15231454
  10. Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats.
    World J Gastroenterol. 2006 Apr 21;12(15):2369-74 PMID: 16688827
  11. New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata.
    Planta Med. 2009 Apr;75(5):512-6 PMID: 19189245
  12. Probing inhibitory effects of Antrodia camphorata isolates using insect cell-based impedance spectroscopy: inhibition vs chemical structure.
    Chem Res Toxicol. 2008 Nov;21(11):2127-33 PMID: 18816072
  13. Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway.
    Food Chem Toxicol. 2007 Jul;45(7):1249-57 PMID: 17316946
  14. Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease.
    Phytother Res. 2009 Apr;23(4):582-4 PMID: 19003946
  15. Ganoderma - a therapeutic fungal biofactory.
    Phytochemistry. 2006 Sep;67(18):1985-2001 PMID: 16905165
  16. Effects of antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells.
    Chin J Physiol. 2008 Apr 30;51(2):78-84 PMID: 18666710
  17. Phylogenetic analysis of Antrodia species and Antrodia camphorata inferred from internal transcribed spacer region.
    Antonie Van Leeuwenhoek. 2007 Apr;91(3):267-76 PMID: 17072535
  18. Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate.
    J Ethnopharmacol. 2008 Nov 20;120(2):196-203 PMID: 18778764
  19. Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway.
    Int Immunopharmacol. 2005 Dec;5(13-14):1914-25 PMID: 16275626
  20. Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes.
    J Food Sci. 2008 Sep;73(7):H179-85 PMID: 18803715
  21. Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.
    J Nat Prod. 2004 Jan;67(1):46-8 PMID: 14738384
  22. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action.
    Toxicol Appl Pharmacol. 2004 Dec 1;201(2):186-93 PMID: 15541758
  23. Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata.
    Acta Pharmacol Sin. 2007 Feb;28(2):258-67 PMID: 17241529
  24. Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated from the Fruiting Body of Antrodia camphorate.
    Evid Based Complement Alternat Med. 2011;2011:984027 PMID: 19293251
  25. Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture.
    J Ethnopharmacol. 2005 Aug 22;100(1-2):158-67 PMID: 15949907
  26. The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway.
    Life Sci. 2003 Oct 10;73(21):2769-83 PMID: 13679244
  27. Natural health products, modulation of immune function and prevention of chronic diseases.
    Evid Based Complement Alternat Med. 2005 Dec;2(4):513-20 PMID: 16322809
  28. Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages.
    J Nat Prod. 2008 Jul;71(7):1258-61 PMID: 18522430
  29. Regulatory T cells, a potent immunoregulatory target for CAM researchers: modulating tumor immunity, autoimmunity and alloreactive immunity (III).
    Evid Based Complement Alternat Med. 2006 Sep;3(3):309-16 PMID: 16951715
  30. Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats.
    J Ethnopharmacol. 2007 Mar 1;110(1):160-4 PMID: 17092673
  31. A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.
    Planta Med. 2007 Oct;73(13):1412-5 PMID: 17932820
  32. Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage.
    J Ethnopharmacol. 2008 Jul 23;118(2):237-45 PMID: 18486375
  33. Research on Nutrition and Cancer: The Importance of the Standardized Dietary Assessments.
    Asian Pac J Cancer Prev. 2002;3(2):177-180 PMID: 12718599
  34. The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.
    J Ethnopharmacol. 2008 Aug 13;118(3):387-95 PMID: 18571350
  35. Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells.
    Nutr Cancer. 2007;57(1):111-21 PMID: 17516868
  36. Ayurveda and traditional Chinese medicine: a comparative overview.
    Evid Based Complement Alternat Med. 2005 Dec;2(4):465-73 PMID: 16322803
  37. Antrodia camphorata in submerged culture protects low density lipoproteins against oxidative modification.
    Am J Chin Med. 2006;34(2):217-31 PMID: 16552834
  38. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata.
    Cancer Lett. 2006 Jan 18;231(2):215-27 PMID: 16399223
  39. Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts.
    J Ethnopharmacol. 2007 Oct 8;114(1):78-85 PMID: 17822865
  40. Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes.
    Life Sci. 2002 Jun 14;71(4):469-82 PMID: 12044846
  41. Proteomic analysis of the effect of Antrodia camphorata extract on human lung cancer A549 cell.
    Proteomics. 2006 Feb;6(3):826-35 PMID: 16411266
  42. Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata.
    Lett Appl Microbiol. 2007 Apr;44(4):387-92 PMID: 17397476
  43. Fermented Antrodia cinnamomea extract protects rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family.
    J Agric Food Chem. 2008 Feb 13;56(3):865-74 PMID: 18186605
  44. Antioxidant properties of Antrodia camphorata in submerged culture.
    J Agric Food Chem. 2002 May 22;50(11):3322-7 PMID: 12010005
  45. Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells.
    Life Sci. 2005 May 13;76(26):3029-42 PMID: 15850596
  46. Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action.
    J Ethnopharmacol. 2007 Aug 15;113(1):45-53 PMID: 17590297
  47. Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway.
    J Agric Food Chem. 2005 Jul 13;53(14):5559-64 PMID: 15998114
  48. Complementary and Alternative Medicine Approaches for Pediatric Pain: A Review of the State-of-the-science.
    Evid Based Complement Alternat Med. 2005 Jun;2(2):149-159 PMID: 15937555
  49. Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-chih) in spontaneously hypertensive rats.
    Biosci Biotechnol Biochem. 2007 Jan;71(1):23-30 PMID: 17213674
  50. Cyclodextrin-modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata.
    Electrophoresis. 2009 Jun;30(11):1967-75 PMID: 19517437
  51. Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells.
    J Ethnopharmacol. 2007 Jan 3;109(1):93-103 PMID: 16930895
  52. Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A.
    Arch Toxicol. 2009 Feb;83(2):121-9 PMID: 18709356
  53. Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.
    J Ethnopharmacol. 2009 Jan 21;121(2):194-212 PMID: 19061947
  54. Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis.
    FEMS Microbiol Lett. 2005 Mar 1;244(1):213-9 PMID: 15727843
  55. Antiangiogenic activities of polysaccharides isolated from medicinal fungi.
    FEMS Microbiol Lett. 2005 Aug 15;249(2):247-54 PMID: 16046081
  56. Anti-inflammatory benzenoids from Antrodia camphorata.
    J Nat Prod. 2007 Jun;70(6):989-92 PMID: 17559265
  57. Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata.
    J Agric Food Chem. 2008 Aug 27;56(16):7017-22 PMID: 18642845
  58. Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species.
    FEMS Microbiol Lett. 2004 Feb 9;231(1):137-43 PMID: 14769478
  59. Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells.
    Cancer Lett. 2009 Nov 18;285(1):73-9 PMID: 19477064
  60. Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects.
    FEMS Microbiol Lett. 2002 Mar 19;209(1):63-7 PMID: 12007655
  61. Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats.
    J Agric Food Chem. 2003 Mar 12;51(6):1571-7 PMID: 12617586
  62. Zhankuic acid F: a new metabolite from a formosan fungus Antrodia cinnamomea.
    Planta Med. 1997 Feb;63(1):86-8 PMID: 17252333
  63. Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors.
    Life Sci. 2006 Jun 13;79(3):252-8 PMID: 16443241
  64. The pharmacological potential of mushrooms.
    Evid Based Complement Alternat Med. 2005 Sep;2(3):285-99 PMID: 16136207
  65. Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts.
    Cancer Lett. 2006 Nov 8;243(1):109-19 PMID: 16455193
  66. New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum.
    J Nat Prod. 1995 Nov;58(11):1655-61 PMID: 8594142
  67. Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
    J Nat Prod. 2006 Apr;69(4):689-91 PMID: 16643055
  68. An Extract of Antrodia camphorata Mycelia Attenuates the Progression of Nephritis in Systemic Lupus Erythematosus-Prone NZB/W F1 Mice.
    Evid Based Complement Alternat Med. 2011;2011:465894 PMID: 18955361
  69. In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.
    Toxicol Appl Pharmacol. 2008 Mar 1;227(2):291-8 PMID: 18078970
  70. Modulation of Immune Functions by Foods.
    Evid Based Complement Alternat Med. 2004 Dec;1(3):241-250 PMID: 15841257
  71. Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.
    Int Immunopharmacol. 2008 Mar;8(3):458-67 PMID: 18279800
  72. Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum.
    Nutr Cancer. 2009;61(1):16-26 PMID: 19116872
  73. Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata.
    Food Chem Toxicol. 2007 Jul;45(7):1107-15 PMID: 17391824
  74. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential.
    Int Immunopharmacol. 2006 Mar;6(3):317-33 PMID: 16428067
Article Info
Journal
Evidence-based complementary and alternative medicine : eCAM
Abbr.
Evid Based Complement Alternat Med
ISSN
1741-4288
DOI
10.1093/ecam/nep108
Published
2011-00-00
Epub
2011-00-03
Pages
212641
Language
English
Region
United States
NLM ID
101215021
PMCID
PMC3095428
External Links
PubMed source DOI: 10.1093/ecam/nep108 PMC Full Text
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