Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.

Journal of natural products ·Vol. 67 ·No. 1 ·2004-01-00 ·Pages 46-8

Nakamura N, Hirakawa A, Gao JJ, Kakuda H, Shiro M, Komatsu Y, Sheu CC, Hattori M

Abstract

Five new maleic and succinic acid derivatives were isolated from the mycelium of Antrodia camphorata. Their structures were determined by various spectroscopic means. Maleimide derivatives 2 and 3 showed appreciable cytotoxic activity against LLC cells.

MeSH Terms

Antineoplastic Agents/chemistry,isolation & purification,pharmacology Crystallography, X-Ray Drug Screening Assays, Antitumor Maleates/chemistry,isolation & purification,pharmacology Medicine, Chinese Traditional Molecular Structure Polyporaceae/chemistry Succinic Acid/chemistry,isolation & purification,pharmacology Taiwan Tumor Cells, Cultured

Chemicals

Antineoplastic Agents Maleates maleic acid Succinic Acid

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Nakamura Norio

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

Hirakawa Akiko

Gao Jiang-Jing

Kakuda Hiroko

Shiro Motoo

Komatsu Yasuhiro

Sheu Chia-chin

Hattori Masao

Article Info

Journal

Journal of natural products

Abbr.

J Nat Prod

ISSN

0163-3864

DOI

10.1021/np030293k

Published

2004-01-00

Pages

46-8

Language

English

Region

United States

NLM ID

7906882

Subset

External Links

PubMed source DOI: 10.1021/np030293k View journal details

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Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.

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