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PMID: 19648918 Published · ppublish English Letter

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

Nature genetics ·Vol. 41 ·No. 9 ·2009-09-00 ·Pages 986-90

Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, LaCroix A, Zheng W, Albanes D, Bamlet W, Berg CD, Berrino F, Bingham S, Buring JE, Bracci PM, Canzian F, Clavel-Chapelon F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Fox JW, Gallinger S, Gaziano JM, Giovannucci EL, Goggins M, González CA, Hallmans G, Hankinson SE, Hassan M, Holly EA, Hunter DJ, Hutchinson A, Jackson R, Jacobs KB, Jenab M, Kaaks R, Klein AP, Kooperberg C, Kurtz RC, Li D, Lynch SM, Mandelson M, McWilliams RR, Mendelsohn JB, Michaud DS, Olson SH, Overvad K, Patel AV, Peeters PH, Rajkovic A, Riboli E, Risch HA, Shu XO, Thomas G, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hartge P, Hoover RN

Abstract

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

MeSH Terms
ABO Blood-Group System/genetics Alleles Case-Control Studies Chromosomes, Human, Pair 9 Cohort Studies Female Gene Frequency Genetic Predisposition to Disease Genetic Variation Genome-Wide Association Study Genotype Haplotypes Humans Introns Linkage Disequilibrium Logistic Models Male Odds Ratio Pancreatic Neoplasms/genetics Polymorphism, Single Nucleotide Prospective Studies Risk Factors United States
Chemicals
ABO Blood-Group System
Authors & Affiliations
71 authors, click to expand affiliations / ORCID
Amundadottir Laufey
Kraft Peter
Stolzenberg-Solomon Rachael Z
Fuchs Charles S
Petersen Gloria M
Arslan Alan A
Bueno-de-Mesquita H Bas
Gross Myron
Helzlsouer Kathy
Jacobs Eric J
LaCroix Andrea
Zheng Wei
Albanes Demetrius
Bamlet William
Berg Christine D
Berrino Franco
Bingham Sheila
Buring Julie E
Bracci Paige M
Canzian Federico
Clavel-Chapelon Françoise
Clipp Sandra
Cotterchio Michelle
de Andrade Mariza
Duell Eric J
Fox John W
Gallinger Steven
Gaziano J Michael
Giovannucci Edward L
Goggins Michael
González Carlos A
Hallmans Göran
Hankinson Susan E
Hassan Manal
Holly Elizabeth A
Hunter David J
Hutchinson Amy
Jackson Rebecca
Jacobs Kevin B
Jenab Mazda
Kaaks Rudolf
Klein Alison P
Kooperberg Charles
Kurtz Robert C
Li Donghui
Lynch Shannon M
Mandelson Margaret
McWilliams Robert R
Mendelsohn Julie B
Michaud Dominique S
Olson Sara H
Overvad Kim
Patel Alpa V
Peeters Petra H M
Rajkovic Aleksandar
Riboli Elio
Risch Harvey A
Shu Xiao-Ou
Thomas Gilles
Tobias Geoffrey S
Trichopoulos Dimitrios
Van Den Eeden Stephen K
Virtamo Jarmo
Wactawski-Wende Jean
Wolpin Brian M
Yu Herbert
Yu Kai
Zeleniuch-Jacquotte Anne
Chanock Stephen J
Hartge Patricia
Hoover Robert N
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.429
Published
2009-09-00
Epub
2009-00-02
Pages
986-90
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC2839871
Subset
IM
Grants
NCI NIH HHS · P50 CA102701-08 · United States
NCI NIH HHS · R01 CA082729 · United States
NCI NIH HHS · P50 CA062924-140011 · United States
NCI NIH HHS · R01 CA124908 · United States
NCI NIH HHS · P50 CA102701 · United States
NCI NIH HHS · R01 CA097193 · United States
NCI NIH HHS · P50 CA062924 · United States
Intramural NIH HHS · Z01 CP010193-01 · United States
NCI NIH HHS · P50 CA062924-150011 · United States
NCI NIH HHS · P50 CA062924-160011 · United States
Corrections
CommentIn
PMID: 26674825
External Links
PubMed source DOI: 10.1038/ng.429 PMC Full Text View journal details
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