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PMID: 19644558 Published · ppublish English Journal Article

MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast Cancer.

Journal of oncology ·Vol. 2009 ·2009-00-00 ·Pages 305420

Ng EK, Wong CL, Ma ES, Kwong A

Abstract

MicroRNAs are small nonprotein-coding RNAs that regulate the expressions of a wide variety of genes by sequence-specific base pairing on the 3'UTR of mRNA targets resulting in mRNA degradation or inhibition of translation. Aberrant expressions of miRNAs have been linked to tumor development, metastasis, diagnosis, prognosis, and therapy response in human breast cancer. Some miRNAs have been considered to have potential clinical applications as a tool for breast cancer prognosis and therapy. Here we describe and discuss lines of evidence supporting the important relationship between miRNAs and breast cancer, and its therapeutic strategies.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ng Enders K O
Department of Surgery, The University of Hong Kong, Hong Kong.
Wong Chris L P
Ma Edmond S K
Kwong Ava
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Article Info
Journal
Journal of oncology
Abbr.
J Oncol
ISSN
1687-8450
DOI
10.1155/2009/305420
Published
2009-00-00
Epub
2009-00-27
Pages
305420
Language
English
Region
Egypt
NLM ID
101496537
PMCID
PMC2716485
External Links
PubMed source DOI: 10.1155/2009/305420 PMC Full Text
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