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PMID: 19548020 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Bioinformatic characterization of p-type ATPases encoded within the fully sequenced genomes of 26 eukaryotes.

The Journal of membrane biology ·Vol. 229 ·No. 3 ·2009-06-00 ·Pages 115-30

Thever MD, Saier MH

Abstract

P-type ATPases play essential roles in numerous processes, which in humans include nerve impulse propagation, relaxation of muscle fibers, secretion and absorption in the kidney, acidification of the stomach and nutrient absorption in the intestine. Published evidence suggests that uncharacterized families of P-type ATPases with novel specificities exist. In this study, the fully sequenced genomes of 26 eukaryotes, including animals, plants, fungi and unicellular eukaryotes, were analyzed for P-type ATPases. We report the organismal distributions, phylogenetic relationships, probable topologies and conserved motifs of nine functionally characterized families and 13 uncharacterized families of these enzyme transporters. We have classified these proteins according to the conventions of the functional and phylogenetic IUBMB-approved transporter classification system ( www.tcdb.org , Saier et al. in Nucleic Acids Res 34:181-186, 2006; Nucleic Acids Res 37:274-278, 2009).

MeSH Terms
Adenosine Triphosphatases/classification,genetics Animals Computational Biology Eukaryotic Cells/metabolism Humans Phylogeny Plant Proteins/classification,genetics
Chemicals
Plant Proteins Adenosine Triphosphatases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thever Mark D
Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0116, CA, USA. markthever@gmail.com
Saier Milton H
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
1432-1424
DOI
10.1007/s00232-009-9176-2
Email
markthever@gmail.com
Published
2009-06-00
Epub
2009-00-23
Pages
115-30
Language
English
Region
United States
NLM ID
0211301
PMCID
PMC2709905
Subset
IM
Grants
NIGMS NIH HHS · R01 GM077402 · United States
NIGMS NIH HHS · GM077402 · United States
External Links
PubMed source DOI: 10.1007/s00232-009-9176-2 PMC Full Text View journal details
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