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PMID: 19527680 Published · ppublish English Journal Article Review

SR/ER-mitochondrial local communication: calcium and ROS.

Biochimica et biophysica acta ·Vol. 1787 ·No. 11 ·2009-11-00 ·Pages 1352-62

Csordás G, Hajnóczky G

Abstract

Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER), which support signal transduction and biosynthetic pathways and affect organellar distribution. Recently, these junctions have received attention because of their pivotal role in mediating calcium signal propagation to the mitochondria, which is important for both ATP production and mitochondrial cell death. Many of the SR/ER-mitochondrial calcium transporters and signaling proteins are sensitive to redox regulation and are directly exposed to the reactive oxygen species (ROS) produced in the mitochondria and SR/ER. Although ROS has been emerging as a novel signaling entity, the redox signaling of the SR/ER-mitochondrial interface is yet to be elucidated. We describe here possible mechanisms of the mutual interaction between local Ca(2+) and ROS signaling in the control of SR/ER-mitochondrial function.

MeSH Terms
Animals Calcium/metabolism Calcium Signaling Endoplasmic Reticulum/metabolism Humans Inositol 1,4,5-Trisphosphate Receptors/physiology Mitochondria/metabolism Reactive Oxygen Species/metabolism Ryanodine Receptor Calcium Release Channel/physiology Sarcoplasmic Reticulum/metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases/physiology
Chemicals
Inositol 1,4,5-Trisphosphate Receptors Reactive Oxygen Species Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Calcium-Transporting ATPases ATP2A2 protein, human Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Csordás György
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Gyorgy.Csordas@jefferson.edu
Hajnóczky György
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbabio.2009.06.004
Email
gyorgy.csordas@jefferson.edu
Published
2009-11-00
Epub
2009-00-13
Pages
1352-62
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC2738971
Subset
IM
Grants
NIDDK NIH HHS · R01 DK051526 · United States
NIDDK NIH HHS · R01 DK051526-12 · United States
NIGMS NIH HHS · R01 GM059419 · United States
NIGMS NIH HHS · R01 GM059419-08 · United States
External Links
PubMed source DOI: 10.1016/j.bbabio.2009.06.004 PMC Full Text
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