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PMID: 17699879 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

ER-mitochondria communication. How privileged?

Physiology (Bethesda, Md.) ·Vol. 22 ·2007-08-00 ·Pages 261-8

Franzini-Armstrong C

Abstract

Mitochondria have a low affinity for Ca(2+), but they take up these ions during normal cell activity because they are in close proximity to the sites of calcium entry into the cell and of internal Ca(2+) release. This gives mitochondria privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.

MeSH Terms

Animals Calcium/metabolism Endoplasmic Reticulum/physiology Homeostasis/physiology Humans Mice Mitochondria, Muscle/physiology Muscle, Skeletal/metabolism Rats Sarcoplasmic Reticulum/physiology

Chemicals

Calcium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Franzini-Armstrong Clara

Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. armstroc@mail.med.upenn.edu

Article Info

Journal

Physiology (Bethesda, Md.)

Abbr.

Physiology (Bethesda)

ISSN

1548-9213

DOI

10.1152/physiol.00017.2007

armstroc@mail.med.upenn.edu

Published

2007-08-00

Pages

261-8

Language

English

Region

United States

NLM ID

101208185

Subset

Grants

NHLBI NIH HHS · R01 HL48093 · United States

External Links

PubMed source DOI: 10.1152/physiol.00017.2007 View journal details

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