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PMID: 19526189 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

RBR ubiquitin ligases: Diversification and streamlining in animal lineages.

Journal of molecular evolution ·Vol. 69 ·No. 1 ·2009-07-00 ·Pages 54-64

Marín I

Abstract

The patterns of emergence and disappearance in animal species of genes encoding RBR ubiquitin ligases are described. RBR genes can be classified into subfamilies (Parkin, Ariadne, Dorfin, ARA54, etc.) according to sequence and structural data. Here, I show that most animal-specific RBR subfamilies emerged early in animal evolution, and that ancient animals, before the cnidarian/bilaterian split, had a set of RBR genes, which was as complex as the one currently found in mammals. However, some lineages (nematodes, dipteran insects) have recently suffered multiple losses, leading to a highly simplified set of RBR genes. Genes of a particular RBR subfamily, characterized by containing a helicase domain and so far found only in plants, are present also in some animal species. The meaning of these patterns of diversification and streamlining are discussed at the light of functional data. Extreme evolutionary conservation may be related to gene products having housekeeping functions.

MeSH Terms
Animals Cnidaria/genetics DEAD-box RNA Helicases/genetics Evolution, Molecular Phylogeny Placozoa/genetics Protein Structure, Tertiary/genetics Sequence Analysis, DNA Ubiquitin-Protein Ligases/genetics
Chemicals
Ubiquitin-Protein Ligases DEAD-box RNA Helicases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Marín Ignacio
Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Spain. imarin@ibv.csic.es
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
1432-1432
DOI
10.1007/s00239-009-9252-3
Email
imarin@ibv.csic.es
Published
2009-07-00
Epub
2009-00-13
Pages
54-64
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/s00239-009-9252-3 View journal details
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