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PMID: 19381141 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Autophagy genes in immunity.

Nature immunology ·Vol. 10 ·No. 5 ·2009-05-00 ·Pages 461-70

Virgin HW, Levine B

Abstract

In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracellular pathogens, are sequestered in a double-membrane-bound autophagosome and delivered to the lysosome for degradation. This pathway has been linked to diverse aspects of innate and adaptive immunity, including pathogen resistance, production of type I interferon, antigen presentation, tolerance and lymphocyte development, as well as the negative regulation of cytokine signaling and inflammation. Most of these links have emerged from studies in which genes encoding molecules involved in autophagy are inactivated in immune effector cells. However, it is not yet known whether all of the critical functions of such genes in immunity represent 'classical autophagy' or possible as-yet-undefined autophagolysosome-independent functions of these genes. This review summarizes phenotypes that result from the inactivation of autophagy genes in the immune system and discusses the pleiotropic functions of autophagy genes in immunity.

MeSH Terms
Animals Autophagy/genetics,immunology Humans Immunity/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Virgin Herbert W
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. virgin@wustl.edu
Levine Beth
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.1726
Email
virgin@wustl.edu
Published
2009-05-00
Pages
461-70
Language
English
Region
United States
NLM ID
100941354
PMCID
PMC2715365
Subset
IM
Grants
NIAID NIH HHS · R01 AI065982 · United States
NIAID NIH HHS · R01 AI054483 · United States
NIAID NIH HHS · R01 AI151267 · United States
NCI NIH HHS · R01 CA074730 · United States
NIAID NIH HHS · R01 AI051367 · United States
NIAID NIH HHS · U54 AI057160 · United States
NCI NIH HHS · R01 CA109618 · United States
NCI NIH HHS · R01 CA096511 · United States
Howard Hughes Medical Institute · United States
NIAID NIH HHS · R01 AI051367-06 · United States
External Links
PubMed source DOI: 10.1038/ni.1726 PMC Full Text View journal details
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