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PMID: 19374683 Published · ppublish English Journal Article Review

Abeta aggregation and possible implications in Alzheimer's disease pathogenesis.

Journal of cellular and molecular medicine ·Vol. 13 ·No. 3 ·2009-03-00 ·Pages 412-21

Bharadwaj PR, Dubey AK, Masters CL, Martins RN, Macreadie IG

Abstract

Amyloid beta protein (Abeta) has been associated with Alzheimer's disease (AD) because it is a major component of the extracellular plaque found in AD brains. Increased Abeta levels correlate with the cognitive decline observed in AD. Sporadic AD cases are thought to be chiefly associated with lack of Abeta clearance from the brain, unlike familial AD which shows increased Abeta production. Abeta aggregation leading to deposition is an essential event in AD. However, the factors involved in Abeta aggregation and accumulation in sporadic AD have not been completely characterized. This review summarizes studies that have examined the factors that affect Abeta aggregation and toxicity. By necessity these are studies that are performed with recombinant-derived or chemically synthesized Abeta. The studies therefore are not done in animals but in cell culture, which includes neuronal cells, other mammalian cells and, in some cases, non-mammalian cells that also appear susceptible to Abeta toxicity. An understanding of Abeta oligomerization may lead to better strategies to prevent AD.

MeSH Terms
Alzheimer Disease/metabolism,pathology Amyloid beta-Peptides/chemistry,metabolism Animals Humans Plaque, Amyloid/pathology Protein Folding Protein Structure, Quaternary
Chemicals
Amyloid beta-Peptides
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bharadwaj Prashant R
CSIRO Molecular and Health Technologies and P-Health Flagship, 343 Royal Parade, Parkville, Victoria, Australia.
Dubey Ashok K
Masters Colin L
Martins Ralph N
Macreadie Ian G
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Article Info
Journal
Journal of cellular and molecular medicine
Abbr.
J Cell Mol Med
ISSN
1582-4934
DOI
10.1111/j.1582-4934.2009.00609.x
Published
2009-03-00
Pages
412-21
Language
English
Region
England
NLM ID
101083777
PMCID
PMC3822505
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1582-4934.2009.00609.x PMC Full Text View journal details
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