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PMID: 19373545 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Developmental function of Nm23/awd: a mediator of endocytosis.

Molecular and cellular biochemistry ·Vol. 329 ·No. 1-2 ·2009-09-00 ·Pages 35-44

Nallamothu G, Dammai V, Hsu T

Abstract

The metastasis suppressor gene Nm23 is highly conserved from yeast to human, implicating a critical developmental function. Studies in cultured mammalian cells have identified several potential functions, but many have not been directly verified in vivo. Here, we summarize the studies on the Drosophila homolog of the Nm23 gene, named a bnormal w ing d iscs (awd), which shares 78% amino acid identity with the human Nm23-H1 and H2 isoforms. These studies confirmed that awd gene encodes a nucleoside diphosphate kinase, and provided strong evidence of a role for awd in regulating cell differentiation and motility via regulation of growth factor receptor signaling. The latter function is mainly mediated by control of endocytosis. This review provides a historical account of the discovery and subsequent analyses of the awd gene. We will also discuss the possible molecular function of the Awd protein that underlies the endocytic function.

MeSH Terms
Amino Acid Sequence Animals Drosophila/embryology,genetics Drosophila Proteins/genetics,metabolism Embryo, Nonmammalian Endocytosis/genetics,physiology Gene Expression Regulation, Developmental Genes, Insect Humans Molecular Sequence Data NM23 Nucleoside Diphosphate Kinases/genetics,metabolism Nucleoside-Diphosphate Kinase/genetics,metabolism Sequence Homology, Amino Acid
Chemicals
Drosophila Proteins NM23 Nucleoside Diphosphate Kinases Nucleoside-Diphosphate Kinase awd protein, Drosophila
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nallamothu Gouthami
Department of Pathology and Laboratory Medicine, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas St., Charleston, SC 29425, USA.
Dammai Vincent
Hsu Tien
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
1573-4919
DOI
10.1007/s11010-009-0112-7
Published
2009-09-00
Epub
2009-00-17
Pages
35-44
Language
English
Region
Netherlands
NLM ID
0364456
PMCID
PMC2721904
Subset
IM
Grants
NCI NIH HHS · R01 CA128002 · United States
NCI NIH HHS · R01 CA128002-03 · United States
NCI NIH HHS · R01 CA109860 · United States
NCI NIH HHS · R01CA128002 · United States
NIGMS NIH HHS · R01 GM057843 · United States
NIGMS NIH HHS · R01GM57843 · United States
NIGMS NIH HHS · R01 GM057843-08 · United States
External Links
PubMed source DOI: 10.1007/s11010-009-0112-7 PMC Full Text View journal details
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